Developmental outcomes of extremely preterm infants born to adolescent mothers

Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

BACKGROUND AND OBJECTIVES: Extremely preterm infants and infants born to adolescent mothers are at risk for adverse developmental. The objectives were to evaluate development and behavior outcomes of extremely low birth weight (ELBW) infants born to adolescent mothers <20 compared with adult mothers ≥20 years and to identify socioeconomic risk factors that affect outcomes. METHODS: Retrospective cohort analysis of 211 infants >27 weeks of adolescent mothers and 1723 infants of adult mothers at Neonatal Research Network centers from 2008 to 2011. Groups were compared and regression models were run to predict 18- to 22-month adverse outcomes. Primary outcomes were Bayley-III scores, neurodevelopmental impairment, and Brief Infant Toddler Social Emotional Assessment problem scores (BITSEA/P) ≥75th percentile. RESULTS: Adolescent mothers were more often single, Hispanic, less educated, and had public insurance. By 18 to 22 months, their children had significantly increased rates of having lived ≥3 places (21% vs 9%), state supervision (7% vs 3%), rehospitalization (56% vs 46%), and BITSEA/P ≥75th percentile (50% vs 32%) and nonsignificant Bayley-III language scores <85 (56% vs 49%, P = .07). In regression analysis, children of adolescent mothers were more likely to have BITSEA/P ≥75th percentile (relative risk 1.50, 95% confidence interval 1.08-2.07). Living ≥3 places and nonwhite race were predictors of adverse behavior. State supervision was an independent predictor of each Bayley-III composite <70 and neurodevelopmental impairment. CONCLUSIONS: ELBW infants of adolescent mothers experience high social and environmental risks that are associated with adverse behavior outcomes. These findings inform the need for comprehensive follow-up, coordinated care services, and behavior interventions for ELBW infants of adolescent mothers.

Original languageEnglish (US)
Pages (from-to)1082-1092
Number of pages11
JournalPediatrics
Volume135
Issue number6
DOIs
StatePublished - Jun 1 2015

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Extremely Premature Infants
Mothers
Extremely Low Birth Weight Infant
Aftercare
Insurance
Hispanic Americans
Language
Regression Analysis
Confidence Intervals

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network (2015). Developmental outcomes of extremely preterm infants born to adolescent mothers. Pediatrics, 135(6), 1082-1092. https://doi.org/10.1542/peds.2014-3880

Developmental outcomes of extremely preterm infants born to adolescent mothers. / Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network.

In: Pediatrics, Vol. 135, No. 6, 01.06.2015, p. 1082-1092.

Research output: Contribution to journalArticle

Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network 2015, 'Developmental outcomes of extremely preterm infants born to adolescent mothers', Pediatrics, vol. 135, no. 6, pp. 1082-1092. https://doi.org/10.1542/peds.2014-3880
Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network. Developmental outcomes of extremely preterm infants born to adolescent mothers. Pediatrics. 2015 Jun 1;135(6):1082-1092. https://doi.org/10.1542/peds.2014-3880
Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network. / Developmental outcomes of extremely preterm infants born to adolescent mothers. In: Pediatrics. 2015 ; Vol. 135, No. 6. pp. 1082-1092.
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abstract = "BACKGROUND AND OBJECTIVES: Extremely preterm infants and infants born to adolescent mothers are at risk for adverse developmental. The objectives were to evaluate development and behavior outcomes of extremely low birth weight (ELBW) infants born to adolescent mothers <20 compared with adult mothers ≥20 years and to identify socioeconomic risk factors that affect outcomes. METHODS: Retrospective cohort analysis of 211 infants >27 weeks of adolescent mothers and 1723 infants of adult mothers at Neonatal Research Network centers from 2008 to 2011. Groups were compared and regression models were run to predict 18- to 22-month adverse outcomes. Primary outcomes were Bayley-III scores, neurodevelopmental impairment, and Brief Infant Toddler Social Emotional Assessment problem scores (BITSEA/P) ≥75th percentile. RESULTS: Adolescent mothers were more often single, Hispanic, less educated, and had public insurance. By 18 to 22 months, their children had significantly increased rates of having lived ≥3 places (21{\%} vs 9{\%}), state supervision (7{\%} vs 3{\%}), rehospitalization (56{\%} vs 46{\%}), and BITSEA/P ≥75th percentile (50{\%} vs 32{\%}) and nonsignificant Bayley-III language scores <85 (56{\%} vs 49{\%}, P = .07). In regression analysis, children of adolescent mothers were more likely to have BITSEA/P ≥75th percentile (relative risk 1.50, 95{\%} confidence interval 1.08-2.07). Living ≥3 places and nonwhite race were predictors of adverse behavior. State supervision was an independent predictor of each Bayley-III composite <70 and neurodevelopmental impairment. CONCLUSIONS: ELBW infants of adolescent mothers experience high social and environmental risks that are associated with adverse behavior outcomes. These findings inform the need for comprehensive follow-up, coordinated care services, and behavior interventions for ELBW infants of adolescent mothers.",
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T1 - Developmental outcomes of extremely preterm infants born to adolescent mothers

AU - Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network

AU - Hoffman, Laurie

AU - Bann, Carla

AU - Higgins, Rosemary

AU - Vohr, Betty

AU - Caplan, M. S.

AU - Polin, R. A.

AU - Laptook, A. R.

AU - Hensman, A. M.

AU - Oh, W.

AU - Keszler, M.

AU - Burke, R.

AU - Caskey, M.

AU - Johnson, K.

AU - Alksninis, B.

AU - Leach, T. M.

AU - Stephens, B. E.

AU - Watson, V. E.

AU - Ventura, S.

AU - Basso, K. M.

AU - Vieira, E.

AU - Halbrook, A.

AU - Walsh, M. C.

AU - Fanaroff, A. A.

AU - Hibbs, A. M.

AU - Wilson-Costello, D. E.

AU - Newman, N. S.

AU - Siner, B. S.

AU - Bhola, M.

AU - Yalcinkaya, G.

AU - Friedman, H. G.

AU - Truog, W. E.

AU - Pallotto, E. K.

AU - Kilbride, H. W.

AU - Gauldin, C.

AU - Holmes, A.

AU - Johnson, K.

AU - Schibler, K.

AU - Donovan, E. F.

AU - Bridges, K.

AU - Alexander, B.

AU - Grisby, C.

AU - Hessling, J.

AU - Fischer, E. E.

AU - Jackson, L. D.

AU - Kirker, K.

AU - Mincey, H. L.

AU - Muthig, G.

AU - Gratton, T. L.

AU - Heyne, Roy J

AU - Brion, Luc P

PY - 2015/6/1

Y1 - 2015/6/1

N2 - BACKGROUND AND OBJECTIVES: Extremely preterm infants and infants born to adolescent mothers are at risk for adverse developmental. The objectives were to evaluate development and behavior outcomes of extremely low birth weight (ELBW) infants born to adolescent mothers <20 compared with adult mothers ≥20 years and to identify socioeconomic risk factors that affect outcomes. METHODS: Retrospective cohort analysis of 211 infants >27 weeks of adolescent mothers and 1723 infants of adult mothers at Neonatal Research Network centers from 2008 to 2011. Groups were compared and regression models were run to predict 18- to 22-month adverse outcomes. Primary outcomes were Bayley-III scores, neurodevelopmental impairment, and Brief Infant Toddler Social Emotional Assessment problem scores (BITSEA/P) ≥75th percentile. RESULTS: Adolescent mothers were more often single, Hispanic, less educated, and had public insurance. By 18 to 22 months, their children had significantly increased rates of having lived ≥3 places (21% vs 9%), state supervision (7% vs 3%), rehospitalization (56% vs 46%), and BITSEA/P ≥75th percentile (50% vs 32%) and nonsignificant Bayley-III language scores <85 (56% vs 49%, P = .07). In regression analysis, children of adolescent mothers were more likely to have BITSEA/P ≥75th percentile (relative risk 1.50, 95% confidence interval 1.08-2.07). Living ≥3 places and nonwhite race were predictors of adverse behavior. State supervision was an independent predictor of each Bayley-III composite <70 and neurodevelopmental impairment. CONCLUSIONS: ELBW infants of adolescent mothers experience high social and environmental risks that are associated with adverse behavior outcomes. These findings inform the need for comprehensive follow-up, coordinated care services, and behavior interventions for ELBW infants of adolescent mothers.

AB - BACKGROUND AND OBJECTIVES: Extremely preterm infants and infants born to adolescent mothers are at risk for adverse developmental. The objectives were to evaluate development and behavior outcomes of extremely low birth weight (ELBW) infants born to adolescent mothers <20 compared with adult mothers ≥20 years and to identify socioeconomic risk factors that affect outcomes. METHODS: Retrospective cohort analysis of 211 infants >27 weeks of adolescent mothers and 1723 infants of adult mothers at Neonatal Research Network centers from 2008 to 2011. Groups were compared and regression models were run to predict 18- to 22-month adverse outcomes. Primary outcomes were Bayley-III scores, neurodevelopmental impairment, and Brief Infant Toddler Social Emotional Assessment problem scores (BITSEA/P) ≥75th percentile. RESULTS: Adolescent mothers were more often single, Hispanic, less educated, and had public insurance. By 18 to 22 months, their children had significantly increased rates of having lived ≥3 places (21% vs 9%), state supervision (7% vs 3%), rehospitalization (56% vs 46%), and BITSEA/P ≥75th percentile (50% vs 32%) and nonsignificant Bayley-III language scores <85 (56% vs 49%, P = .07). In regression analysis, children of adolescent mothers were more likely to have BITSEA/P ≥75th percentile (relative risk 1.50, 95% confidence interval 1.08-2.07). Living ≥3 places and nonwhite race were predictors of adverse behavior. State supervision was an independent predictor of each Bayley-III composite <70 and neurodevelopmental impairment. CONCLUSIONS: ELBW infants of adolescent mothers experience high social and environmental risks that are associated with adverse behavior outcomes. These findings inform the need for comprehensive follow-up, coordinated care services, and behavior interventions for ELBW infants of adolescent mothers.

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