Developmental pattern of increased aromatase activity in the Sebright bantam chicken.

F. W. George, J. D. Wilson

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Feathers in the male Sebright bantam chicken are feminized as the result of a mutation that causes an increase in the capacity for estrogen synthesis (aromatase activity) in skin. To determine when during development the increased aromatase activity is expressed, we measured the enzyme in tissue slices of Sebright bantam and control bantam chickens of days 3, 12, and 18 of embryogenesis, on day 1 after hatching, and in mature birds. An assay was used that measures the release of 3H2O from [1 beta-3H]testosterone during the aromatization process. Aromatase activity was expressed in the 3-day-old Sebright embryos, but was not detectable in control embryos of the same age. In older embryos and birds, aromatase activity was assayed in multiple tissues. Enzyme activity was detectable in all tissues examined from day 12 and day 18 Sebright embryos. In control embryos, aromatase was detectable in ovarian but not in extraglandular tissues. The enzyme activity in most tissues of the Sebright decreased within 1 day after hatching and continued to decrease thereafter so that in the adult Sebright, aromatase activity was high only in skin (and skin appendages) and ovary. We conclude that the normal allele of this gene acts to limit the rate of estrogen formation in extraglandular tissues.

Original languageEnglish (US)
Pages (from-to)1203-1207
Number of pages5
JournalEndocrinology
Volume110
Issue number4
StatePublished - Apr 1982

Fingerprint

Aromatase
Chickens
Embryonic Structures
Skin
Birds
Estrogens
Enzymes
Feathers
Embryonic Development
Testosterone
Ovary
Alleles
Mutation
Genes

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

Cite this

Developmental pattern of increased aromatase activity in the Sebright bantam chicken. / George, F. W.; Wilson, J. D.

In: Endocrinology, Vol. 110, No. 4, 04.1982, p. 1203-1207.

Research output: Contribution to journalArticle

George, FW & Wilson, JD 1982, 'Developmental pattern of increased aromatase activity in the Sebright bantam chicken.', Endocrinology, vol. 110, no. 4, pp. 1203-1207.
George, F. W. ; Wilson, J. D. / Developmental pattern of increased aromatase activity in the Sebright bantam chicken. In: Endocrinology. 1982 ; Vol. 110, No. 4. pp. 1203-1207.
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