TY - JOUR
T1 - Developmental programming
T2 - State-of-the-science and future directions-Summary from a Pennington Biomedical symposium
AU - Sutton, Elizabeth F.
AU - Gilmore, L. Anne
AU - Dunger, David B.
AU - Heijmans, Bas T.
AU - Hivert, Marie France
AU - Ling, Charlotte
AU - Martinez, J. Alfredo
AU - Ozanne, Susan E.
AU - Simmons, Rebecca A.
AU - Szyf, Moshe
AU - Waterland, Robert A.
AU - Redman, Leanne M.
AU - Ravussin, Eric
N1 - Publisher Copyright:
© 2016 The Obesity Society.
PY - 2016/5/1
Y1 - 2016/5/1
N2 - Objective On December 8-9, 2014, the Pennington Biomedical Research Center convened a scientific symposium to review the state-of-the-science and future directions for the study of developmental programming of obesity and chronic disease. The objectives of the symposium were to discuss: (i) past and current scientific advances in animal models, population-based cohort studies, and human clinical trials, (ii) the state-of-the-science of epigenetic-based research, and (iii) considerations for future studies. Results This symposium provided a comprehensive assessment of the state of the scientific field and identified research gaps and opportunities for future research in order to understand the mechanisms contributing to the developmental programming of health and disease. Conclusions Identifying the mechanisms which cause or contribute to developmental programming of future generations will be invaluable to the scientific and medical community. The ability to intervene during critical periods of prenatal and early postnatal life to promote lifelong health is the ultimate goal. Considerations for future research including the use of animal models, the study design in human cohorts with considerations about the timing of the intrauterine exposure, and the resulting tissue-specific epigenetic signature were extensively discussed and are presented in this meeting summary.
AB - Objective On December 8-9, 2014, the Pennington Biomedical Research Center convened a scientific symposium to review the state-of-the-science and future directions for the study of developmental programming of obesity and chronic disease. The objectives of the symposium were to discuss: (i) past and current scientific advances in animal models, population-based cohort studies, and human clinical trials, (ii) the state-of-the-science of epigenetic-based research, and (iii) considerations for future studies. Results This symposium provided a comprehensive assessment of the state of the scientific field and identified research gaps and opportunities for future research in order to understand the mechanisms contributing to the developmental programming of health and disease. Conclusions Identifying the mechanisms which cause or contribute to developmental programming of future generations will be invaluable to the scientific and medical community. The ability to intervene during critical periods of prenatal and early postnatal life to promote lifelong health is the ultimate goal. Considerations for future research including the use of animal models, the study design in human cohorts with considerations about the timing of the intrauterine exposure, and the resulting tissue-specific epigenetic signature were extensively discussed and are presented in this meeting summary.
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U2 - 10.1002/oby.21487
DO - 10.1002/oby.21487
M3 - Article
C2 - 27037645
AN - SCOPUS:84963517839
SN - 1930-7381
VL - 24
SP - 1018
EP - 1026
JO - Obesity
JF - Obesity
IS - 5
ER -