Developmental sequelae and neurophysiologic substrates of sensory seeking in infant siblings of children with autism spectrum disorder

Cara R. Damiano-Goodwin, Tiffany G. Woynaroski, David M. Simon, Lisa V. Ibañez, Michael Murias, Anne Kirby, Cassandra R. Newsom, Mark T. Wallace, Wendy L. Stone, Carissa J. Cascio

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

It has been proposed that early differences in sensory responsiveness arise from atypical neural function and produce cascading effects on development across domains. This longitudinal study prospectively followed infants at heightened risk for autism spectrum disorder (ASD) based on their status as younger siblings of children diagnosed with ASD (Sibs-ASD) and infants at relatively lower risk for ASD (siblings of typically developing children; Sibs-TD) to examine the developmental sequelae and possible neurophysiological substrates of a specific sensory response pattern: unusually intense interest in nonsocial sensory stimuli or "sensory seeking." At 18 months, sensory seeking and social orienting were measured with the Sensory Processing Assessment, and a potential neural signature for sensory seeking (i.e., frontal alpha asymmetry) was measured via resting state electroencephalography. At 36 months, infants' social symptomatology was assessed in a comprehensive diagnostic evaluation. Sibs-ASD showed elevated sensory seeking relative to Sibs-TD, and increased sensory seeking was concurrently associated with reduced social orienting across groups and resting frontal asymmetry in Sibs-ASD. Sensory seeking also predicted later social symptomatology. Findings suggest that sensory seeking may produce cascading effects on social development in infants at risk for ASD and that atypical frontal asymmetry may underlie this atypical pattern of sensory responsiveness.

Original languageEnglish (US)
JournalDevelopmental Cognitive Neuroscience
DOIs
StateAccepted/In press - Jan 1 2017

Fingerprint

Siblings
Child Development
Autism Spectrum Disorder
Longitudinal Studies
Electroencephalography

Keywords

  • Autism
  • EEG
  • Frontal asymmetry
  • Infant siblings
  • Longitudinal
  • Sensory

ASJC Scopus subject areas

  • Cognitive Neuroscience

Cite this

Developmental sequelae and neurophysiologic substrates of sensory seeking in infant siblings of children with autism spectrum disorder. / Damiano-Goodwin, Cara R.; Woynaroski, Tiffany G.; Simon, David M.; Ibañez, Lisa V.; Murias, Michael; Kirby, Anne; Newsom, Cassandra R.; Wallace, Mark T.; Stone, Wendy L.; Cascio, Carissa J.

In: Developmental Cognitive Neuroscience, 01.01.2017.

Research output: Contribution to journalArticle

Damiano-Goodwin, Cara R. ; Woynaroski, Tiffany G. ; Simon, David M. ; Ibañez, Lisa V. ; Murias, Michael ; Kirby, Anne ; Newsom, Cassandra R. ; Wallace, Mark T. ; Stone, Wendy L. ; Cascio, Carissa J. / Developmental sequelae and neurophysiologic substrates of sensory seeking in infant siblings of children with autism spectrum disorder. In: Developmental Cognitive Neuroscience. 2017.
@article{db17be5d03dc489097e39840f1178237,
title = "Developmental sequelae and neurophysiologic substrates of sensory seeking in infant siblings of children with autism spectrum disorder",
abstract = "It has been proposed that early differences in sensory responsiveness arise from atypical neural function and produce cascading effects on development across domains. This longitudinal study prospectively followed infants at heightened risk for autism spectrum disorder (ASD) based on their status as younger siblings of children diagnosed with ASD (Sibs-ASD) and infants at relatively lower risk for ASD (siblings of typically developing children; Sibs-TD) to examine the developmental sequelae and possible neurophysiological substrates of a specific sensory response pattern: unusually intense interest in nonsocial sensory stimuli or {"}sensory seeking.{"} At 18 months, sensory seeking and social orienting were measured with the Sensory Processing Assessment, and a potential neural signature for sensory seeking (i.e., frontal alpha asymmetry) was measured via resting state electroencephalography. At 36 months, infants' social symptomatology was assessed in a comprehensive diagnostic evaluation. Sibs-ASD showed elevated sensory seeking relative to Sibs-TD, and increased sensory seeking was concurrently associated with reduced social orienting across groups and resting frontal asymmetry in Sibs-ASD. Sensory seeking also predicted later social symptomatology. Findings suggest that sensory seeking may produce cascading effects on social development in infants at risk for ASD and that atypical frontal asymmetry may underlie this atypical pattern of sensory responsiveness.",
keywords = "Autism, EEG, Frontal asymmetry, Infant siblings, Longitudinal, Sensory",
author = "Damiano-Goodwin, {Cara R.} and Woynaroski, {Tiffany G.} and Simon, {David M.} and Iba{\~n}ez, {Lisa V.} and Michael Murias and Anne Kirby and Newsom, {Cassandra R.} and Wallace, {Mark T.} and Stone, {Wendy L.} and Cascio, {Carissa J.}",
year = "2017",
month = "1",
day = "1",
doi = "10.1016/j.dcn.2017.08.005",
language = "English (US)",
journal = "Developmental Cognitive Neuroscience",
issn = "1878-9293",
publisher = "Elsevier BV",

}

TY - JOUR

T1 - Developmental sequelae and neurophysiologic substrates of sensory seeking in infant siblings of children with autism spectrum disorder

AU - Damiano-Goodwin, Cara R.

AU - Woynaroski, Tiffany G.

AU - Simon, David M.

AU - Ibañez, Lisa V.

AU - Murias, Michael

AU - Kirby, Anne

AU - Newsom, Cassandra R.

AU - Wallace, Mark T.

AU - Stone, Wendy L.

AU - Cascio, Carissa J.

PY - 2017/1/1

Y1 - 2017/1/1

N2 - It has been proposed that early differences in sensory responsiveness arise from atypical neural function and produce cascading effects on development across domains. This longitudinal study prospectively followed infants at heightened risk for autism spectrum disorder (ASD) based on their status as younger siblings of children diagnosed with ASD (Sibs-ASD) and infants at relatively lower risk for ASD (siblings of typically developing children; Sibs-TD) to examine the developmental sequelae and possible neurophysiological substrates of a specific sensory response pattern: unusually intense interest in nonsocial sensory stimuli or "sensory seeking." At 18 months, sensory seeking and social orienting were measured with the Sensory Processing Assessment, and a potential neural signature for sensory seeking (i.e., frontal alpha asymmetry) was measured via resting state electroencephalography. At 36 months, infants' social symptomatology was assessed in a comprehensive diagnostic evaluation. Sibs-ASD showed elevated sensory seeking relative to Sibs-TD, and increased sensory seeking was concurrently associated with reduced social orienting across groups and resting frontal asymmetry in Sibs-ASD. Sensory seeking also predicted later social symptomatology. Findings suggest that sensory seeking may produce cascading effects on social development in infants at risk for ASD and that atypical frontal asymmetry may underlie this atypical pattern of sensory responsiveness.

AB - It has been proposed that early differences in sensory responsiveness arise from atypical neural function and produce cascading effects on development across domains. This longitudinal study prospectively followed infants at heightened risk for autism spectrum disorder (ASD) based on their status as younger siblings of children diagnosed with ASD (Sibs-ASD) and infants at relatively lower risk for ASD (siblings of typically developing children; Sibs-TD) to examine the developmental sequelae and possible neurophysiological substrates of a specific sensory response pattern: unusually intense interest in nonsocial sensory stimuli or "sensory seeking." At 18 months, sensory seeking and social orienting were measured with the Sensory Processing Assessment, and a potential neural signature for sensory seeking (i.e., frontal alpha asymmetry) was measured via resting state electroencephalography. At 36 months, infants' social symptomatology was assessed in a comprehensive diagnostic evaluation. Sibs-ASD showed elevated sensory seeking relative to Sibs-TD, and increased sensory seeking was concurrently associated with reduced social orienting across groups and resting frontal asymmetry in Sibs-ASD. Sensory seeking also predicted later social symptomatology. Findings suggest that sensory seeking may produce cascading effects on social development in infants at risk for ASD and that atypical frontal asymmetry may underlie this atypical pattern of sensory responsiveness.

KW - Autism

KW - EEG

KW - Frontal asymmetry

KW - Infant siblings

KW - Longitudinal

KW - Sensory

UR - http://www.scopus.com/inward/record.url?scp=85031031294&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85031031294&partnerID=8YFLogxK

U2 - 10.1016/j.dcn.2017.08.005

DO - 10.1016/j.dcn.2017.08.005

M3 - Article

JO - Developmental Cognitive Neuroscience

JF - Developmental Cognitive Neuroscience

SN - 1878-9293

ER -