Developmental signals do not further accentuate nonuniform postpneumonectomy compensatory lung growth

Priya Ravikumar, Cuneyt Yilmaz, D. Merrill Dane, Robert L. Johnson, Aaron S. Estrera, Connie C W Hsia

Research output: Contribution to journalArticle

18 Scopus citations

Abstract

Mechanical forces imposed on lung tissue constitute major stimuli for normal lung development and postpneumonectomy (PNX) compensatory growth and remodeling. Superimposing developmental signals on PNX signals augments compensatory alveolar growth but exaggerates airway-parenchymal dissociation (i.e., dysanaptic lung growth); the latter tends to offset benefits derived from the former. In adult dogs after PNX, lobar expansion and growth of the remaining lobes were markedly nonuniform (Ravikumar et al. J Appl Physiol 97:1567-1574, 2004). We hypothesized that superimposing developmental and post-PNX signals further accentuates nonuniformity of lobar growth. We used high-resolution computed tomography (HRCT) to follow regional lung expansion and growth in foxhounds undergoing right PNX at 2.5 mo of age compared with litter-matched control (Sham) animals; scans were performed 4 and 10 mo following surgery, i.e., before and after somatic maturity. Air and tissue volumes were measured in each lobe; tissue volume estimated by HRCT includes air-free tissue and blood in small vessels <1 mm. Interlobar nonuniformity of tissue volume was absent at 4 mo but evident 10 mo after PNX; growth of the remaining left lower lobe gradually lagged behind other lobes. At maturity, nonuniformity of lobar growth in pneumonectomized puppies was similar to that previously reported in pneumonectomized adults. We conclude that superimposing developmental and post-PNX signals enhances some aspects of compensatory lung growth and remodeling without altering its nonuniform spatial distribution.

Original languageEnglish (US)
Pages (from-to)1170-1177
Number of pages8
JournalJournal of applied physiology
Volume102
Issue number3
DOIs
StatePublished - Mar 2007

Keywords

  • Dog
  • High-resolution computed tomography scan
  • Lung resection
  • Lung tissue volume
  • Mechanical signal

ASJC Scopus subject areas

  • Physiology
  • Physiology (medical)

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