TY - JOUR
T1 - Dexamethasone Attenuation of Cytokine-Mediated Articular Cartilage Degradation in Experimental Lapine Haemophilus Arthritis
AU - Jafari, Hamid S.
AU - Sáez-Llorens, Xavier
AU - Paris, Maria
AU - Rinderknecht, Stephen
AU - Friedland, Ian
AU - Ehrett, Stuart
AU - Severien, Carlos
AU - Olsen, Kurt D.
AU - Burns, Dennis K.
AU - Harper, Coral F.
AU - Lark, Michael W.
AU - Thonar, Eugene J M A
AU - McCracken, George H.
PY - 1993/12
Y1 - 1993/12
N2 - The role of cytokines in the regulation of articular inflammation and cartilage degradation was evaluated in the rabbit model of Haemophilus influenzae type b arthritis. At 6 and 12 h after intraarticular infection, treatment with IB4 monoclonal antibody to the CD18 leukocyte receptor alone or in combination with dexamethasone resulted in significant reduction of synovial fluid (SF) neutrophil concentration. Treatment with dexamethasone alone was associated with lower SF concentrations of interleukin-1 (lL-1), tumor necrosis factor-α, and strome lysin than in other groups. At 24 h after infection, increased cartilage degradation was detected in untreated controls and in animals treated with IB4 alone or in combination with dexamethasone compared with those treated with dexamethasone alone. Multiple regression analyses indicated SF concentration of IL-1 and strome lysin as the significant predictors of cartilage degradation. These data suggest that IL-1 mediates cartilage degradation by regulation of metalloproteinases, such as stromelysin, during acute experimental bacterial arthritis.
AB - The role of cytokines in the regulation of articular inflammation and cartilage degradation was evaluated in the rabbit model of Haemophilus influenzae type b arthritis. At 6 and 12 h after intraarticular infection, treatment with IB4 monoclonal antibody to the CD18 leukocyte receptor alone or in combination with dexamethasone resulted in significant reduction of synovial fluid (SF) neutrophil concentration. Treatment with dexamethasone alone was associated with lower SF concentrations of interleukin-1 (lL-1), tumor necrosis factor-α, and strome lysin than in other groups. At 24 h after infection, increased cartilage degradation was detected in untreated controls and in animals treated with IB4 alone or in combination with dexamethasone compared with those treated with dexamethasone alone. Multiple regression analyses indicated SF concentration of IL-1 and strome lysin as the significant predictors of cartilage degradation. These data suggest that IL-1 mediates cartilage degradation by regulation of metalloproteinases, such as stromelysin, during acute experimental bacterial arthritis.
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U2 - 10.1093/infdis/168.5.1186
DO - 10.1093/infdis/168.5.1186
M3 - Article
C2 - 7901286
AN - SCOPUS:0027484591
SN - 0022-1899
VL - 168
SP - 1186
EP - 1193
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
IS - 5
ER -