Dexamethasone Attenuation of Cytokine-Mediated Articular Cartilage Degradation in Experimental Lapine Haemophilus Arthritis

Hamid S. Jafari, Xavier Sáez-Llorens, Maria Paris, Stephen Rinderknecht, Ian Friedland, Stuart Ehrett, Carlos Severien, Kurt D. Olsen, Dennis K. Burns, Coral F. Harper, Michael W. Lark, Eugene J M A Thonar, George H. McCracken

Research output: Contribution to journalArticle

27 Scopus citations

Abstract

The role of cytokines in the regulation of articular inflammation and cartilage degradation was evaluated in the rabbit model of Haemophilus influenzae type b arthritis. At 6 and 12 h after intraarticular infection, treatment with IB4 monoclonal antibody to the CD18 leukocyte receptor alone or in combination with dexamethasone resulted in significant reduction of synovial fluid (SF) neutrophil concentration. Treatment with dexamethasone alone was associated with lower SF concentrations of interleukin-1 (lL-1), tumor necrosis factor-α, and strome lysin than in other groups. At 24 h after infection, increased cartilage degradation was detected in untreated controls and in animals treated with IB4 alone or in combination with dexamethasone compared with those treated with dexamethasone alone. Multiple regression analyses indicated SF concentration of IL-1 and strome lysin as the significant predictors of cartilage degradation. These data suggest that IL-1 mediates cartilage degradation by regulation of metalloproteinases, such as stromelysin, during acute experimental bacterial arthritis.

Original languageEnglish (US)
Pages (from-to)1186-1193
Number of pages8
JournalJournal of Infectious Diseases
Volume168
Issue number5
DOIs
StatePublished - Dec 1993

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases

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