Dexamethasone attenuation of cytokine-mediated articular cartilage degradation in experimental lapine Haemophilus arthritis

Hamid S. Jafari, Xavier Sáez-Llorens, Maria Paris, Stephen Rinderknecht, Ian Friedland, Stuart Ehrett, Carlos Severien, Kurt D. Olsen, Dennis K. Burns, Coral F. Harper, Michael W. Lark, Eugene J M A Thonar, George H. McCracken

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

The role of cytokines in the regulation of articular inflammation and cartilage degradation was evaluated in the rabbit model of Haemophilus influenzae type b arthritis. At 6 and 12 h after intraarticular infection, treatment with IB4 monoclonal antibody to the CD18 leukocyte receptor alone or in combination with dexamethasone resulted in significant reduction of synovial fluid (SF) neutrophil concentration. Treatment with dexamethasone alone was associated with lower SF concentrations of interleukin-1 (IL-1), tumor necrosis factor-α, and stromelysin than in other groups. At 24 h after infection, increased cartilage degradation was detected in untreated controls and in animals treated with IB4 alone or in combination with dexamethasone compared with those treated with dexamethasone alone. Multiple regression analyses indicated SF concentration of IL-1 and stromelysin as the significant predictors of cartilage degradation. These data suggest that IL-1 mediates cartilage degradation by regulation of metalloproteinases, such as stromelysin, during acute experimental bacterial arthritis.

Original languageEnglish (US)
Pages (from-to)1186-1193
Number of pages8
JournalJournal of Infectious Diseases
Volume168
Issue number5
StatePublished - Nov 1993

Fingerprint

Haemophilus
Articular Cartilage
Matrix Metalloproteinase 3
Dexamethasone
Arthritis
Synovial Fluid
Interleukin-1
Cytokines
Cartilage
Haemophilus influenzae type b
Infectious Arthritis
Experimental Arthritis
Metalloproteases
Infection
Neutrophils
Leukocytes
Tumor Necrosis Factor-alpha
Monoclonal Antibodies
Regression Analysis
Rabbits

ASJC Scopus subject areas

  • Immunology
  • Public Health, Environmental and Occupational Health

Cite this

Jafari, H. S., Sáez-Llorens, X., Paris, M., Rinderknecht, S., Friedland, I., Ehrett, S., ... McCracken, G. H. (1993). Dexamethasone attenuation of cytokine-mediated articular cartilage degradation in experimental lapine Haemophilus arthritis. Journal of Infectious Diseases, 168(5), 1186-1193.

Dexamethasone attenuation of cytokine-mediated articular cartilage degradation in experimental lapine Haemophilus arthritis. / Jafari, Hamid S.; Sáez-Llorens, Xavier; Paris, Maria; Rinderknecht, Stephen; Friedland, Ian; Ehrett, Stuart; Severien, Carlos; Olsen, Kurt D.; Burns, Dennis K.; Harper, Coral F.; Lark, Michael W.; Thonar, Eugene J M A; McCracken, George H.

In: Journal of Infectious Diseases, Vol. 168, No. 5, 11.1993, p. 1186-1193.

Research output: Contribution to journalArticle

Jafari, HS, Sáez-Llorens, X, Paris, M, Rinderknecht, S, Friedland, I, Ehrett, S, Severien, C, Olsen, KD, Burns, DK, Harper, CF, Lark, MW, Thonar, EJMA & McCracken, GH 1993, 'Dexamethasone attenuation of cytokine-mediated articular cartilage degradation in experimental lapine Haemophilus arthritis', Journal of Infectious Diseases, vol. 168, no. 5, pp. 1186-1193.
Jafari, Hamid S. ; Sáez-Llorens, Xavier ; Paris, Maria ; Rinderknecht, Stephen ; Friedland, Ian ; Ehrett, Stuart ; Severien, Carlos ; Olsen, Kurt D. ; Burns, Dennis K. ; Harper, Coral F. ; Lark, Michael W. ; Thonar, Eugene J M A ; McCracken, George H. / Dexamethasone attenuation of cytokine-mediated articular cartilage degradation in experimental lapine Haemophilus arthritis. In: Journal of Infectious Diseases. 1993 ; Vol. 168, No. 5. pp. 1186-1193.
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