Dexamethasone in the treatment of experimental Haemophilus influenzae type b meningitis

G. A. Syrogiannopoulos, K. D. Olsen, J. S. Reisch, G. H. McCracken

Research output: Contribution to journalArticle

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Abstract

A model of experimental lapin meningitis was used to assess the effect of meningeal inflammation caused by Haemophilus influenzae type b on development of brain edema, increase in intracranial pressure, and production of brain lactate. Four treatments were assessed: (1) dexamethasone alone, (2) dexamethasone plus ceftriaxone, (3) ceftriaxone alone, and (4) no treatment. The brain water content in untreated rabbits with meningitis was 419 ± 10 g of H2O/100g of dry weight after 29 hr of infection (vs. 405 ± 14 in uninfected rabbits; P < .05). In rabbits treated with dexamethasone, ceftriaxone, or both, these values were 404 ± 12, 406 ± 12, and 411 ± 14 g, respectively (P > .05). The cerebrospinal fluid (CSF) pressure and lactate levels were significantly increased in all animals during the 24 hr of meningeal inflammation (P < .005), and these levels were comparably reduced after 9 hr of treatment. Although the values for brain water content, CSF pressure, and lactate concentrations in infected animals treated with ceftriaxone plus dexamethasone were not significantly different from those in animals treated with ceftriaxone alone, the values were consistently lower in the former group.

Original languageEnglish (US)
Pages (from-to)213-219
Number of pages7
JournalJournal of Infectious Diseases
Volume155
Issue number2
StatePublished - 1987

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Haemophilus influenzae type b
Ceftriaxone
Meningitis
Dexamethasone
Cerebrospinal Fluid Pressure
Lactic Acid
Brain
Rabbits
Inflammation
Intracranial Hypertension
Water
Brain Edema
Theoretical Models
Weights and Measures
Infection

ASJC Scopus subject areas

  • Immunology
  • Public Health, Environmental and Occupational Health

Cite this

Dexamethasone in the treatment of experimental Haemophilus influenzae type b meningitis. / Syrogiannopoulos, G. A.; Olsen, K. D.; Reisch, J. S.; McCracken, G. H.

In: Journal of Infectious Diseases, Vol. 155, No. 2, 1987, p. 213-219.

Research output: Contribution to journalArticle

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