Dexamethasone Therapy for Bacterial Meningitis

S. X. Skapek, M. G. Ottolini, P. L. Havens, K. J. Kelly, G. M. Hoffman, S. E. Day, T. B. Rice, K. J. Wendelberger, M. J. Chusid, D. G. Maki, H. M. Feder, G. H. McCracken, M. H. Lebel, A. L. Smith

Research output: Contribution to journalLetter

6 Scopus citations

Abstract

To the Editor: In their report of a prospective trial of corticosteroids as adjunctive therapy for bacterial meningitis, Lebel et al. (Oct. 13 issue)1 concluded that dexamethasone “had a significantly beneficial effect on the inflammatory profile of the cerebrospinal fluid in the first 24 hours of treatment and also on hearing.” On the basis of the reported data, such a conclusion is not entirely accurate. When the results of their two studies are analyzed separately, one finds a statistically significant reduction in the number of children who had seizures, subdural effusions, neurologic abnormalities at the time of discharge, or moderate…

Original languageEnglish (US)
Pages (from-to)463-465
Number of pages3
JournalNew England Journal of Medicine
Volume320
Issue number7
DOIs
StatePublished - Feb 16 1989

ASJC Scopus subject areas

  • Medicine(all)

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    Skapek, S. X., Ottolini, M. G., Havens, P. L., Kelly, K. J., Hoffman, G. M., Day, S. E., Rice, T. B., Wendelberger, K. J., Chusid, M. J., Maki, D. G., Feder, H. M., McCracken, G. H., Lebel, M. H., & Smith, A. L. (1989). Dexamethasone Therapy for Bacterial Meningitis. New England Journal of Medicine, 320(7), 463-465. https://doi.org/10.1056/NEJM198902163200713