Dexamethasone therapy for bacterial meningitis in infants and children

G. H. McCracken, M. H. Lebel

Research output: Contribution to journalArticle

43 Citations (Scopus)

Abstract

On the basis of data in experimental meningitis, it seems prudent to administer dexamethasone concomitantly with the first parenteral dose of antibiotics. We prefer ceftriaxone sodium of cefotaxime sodium for antimicrobial therapy; we have shown that cefuroxime therapy can be associated with delayed sterilization of CSF cultures and with an increased rate of hearing impairment. It should be emphasized that, to date, the favorable effects of dexamethasone therapy have been observed only in patients with H influenzae meningitis; too few patients with meningococcal or pneumococcal meningitis have currently been treated to assess efficacy. Dexamethasone should not be used to treat suspected or proved aseptic or nonbacterial meningitis. Hemoglobin concentration measurements and stool examinations for occult blood should be performed regularly during dexamethasone therapy and the steroid therapy stopped if melena or gross blood is observed.

Original languageEnglish (US)
Pages (from-to)287-289
Number of pages3
JournalAmerican Journal of Diseases of Children
Volume143
Issue number3
StatePublished - 1989

Fingerprint

Bacterial Meningitides
Dexamethasone
Meningitis
Meningococcal Meningitis
Pneumococcal Meningitis
Melena
Therapeutics
Cefuroxime
Occult Blood
Cefotaxime
Ceftriaxone
Hearing Loss
Human Influenza
Hemoglobins
Steroids
Anti-Bacterial Agents

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Dexamethasone therapy for bacterial meningitis in infants and children. / McCracken, G. H.; Lebel, M. H.

In: American Journal of Diseases of Children, Vol. 143, No. 3, 1989, p. 287-289.

Research output: Contribution to journalArticle

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