Dexamethasone therapy in bacterial meningitis.

H. S. Jafari, G. H. McCracken

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

With improved understanding of the pathophysiology of bacterial meningitis, a number of points in the deleterious inflammatory cascade have been identified as possible sites for modulation. Dexamethasone attenuates tissue injury by inhibiting host mediators at several steps in the inflammatory process. Dexamethasone therapy initiated just before or simultaneously with the first parenteral antibiotic dose is recommended for infants older than 6 weeks of age and children with bacterial meningitis. A beneficial effect of steroid therapy administered 12 to 24 hours or more after the first dose of parenteral antibiotics is unlikely. The consistent finding of improved overall neurologic outcome in infants and children with bacterial meningitis caused by the usual meningeal pathogens treated with dexamethasone is the basis for this recommendation, provided that the caveats discussed above are observed.

Original languageEnglish (US)
Pages (from-to)82-88
Number of pages7
JournalPediatric Annals
Volume23
Issue number2
StatePublished - Feb 1994

Fingerprint

Bacterial Meningitides
Dexamethasone
Anti-Bacterial Agents
Nervous System
Therapeutics
Steroids
Wounds and Injuries

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Dexamethasone therapy in bacterial meningitis. / Jafari, H. S.; McCracken, G. H.

In: Pediatric Annals, Vol. 23, No. 2, 02.1994, p. 82-88.

Research output: Contribution to journalArticle

Jafari, H. S. ; McCracken, G. H. / Dexamethasone therapy in bacterial meningitis. In: Pediatric Annals. 1994 ; Vol. 23, No. 2. pp. 82-88.
@article{8418a087b08e4a9d92ee6af8778a6f29,
title = "Dexamethasone therapy in bacterial meningitis.",
abstract = "With improved understanding of the pathophysiology of bacterial meningitis, a number of points in the deleterious inflammatory cascade have been identified as possible sites for modulation. Dexamethasone attenuates tissue injury by inhibiting host mediators at several steps in the inflammatory process. Dexamethasone therapy initiated just before or simultaneously with the first parenteral antibiotic dose is recommended for infants older than 6 weeks of age and children with bacterial meningitis. A beneficial effect of steroid therapy administered 12 to 24 hours or more after the first dose of parenteral antibiotics is unlikely. The consistent finding of improved overall neurologic outcome in infants and children with bacterial meningitis caused by the usual meningeal pathogens treated with dexamethasone is the basis for this recommendation, provided that the caveats discussed above are observed.",
author = "Jafari, {H. S.} and McCracken, {G. H.}",
year = "1994",
month = "2",
language = "English (US)",
volume = "23",
pages = "82--88",
journal = "Pediatric Annals",
issn = "0090-4481",
publisher = "Slack Incorporated",
number = "2",

}

TY - JOUR

T1 - Dexamethasone therapy in bacterial meningitis.

AU - Jafari, H. S.

AU - McCracken, G. H.

PY - 1994/2

Y1 - 1994/2

N2 - With improved understanding of the pathophysiology of bacterial meningitis, a number of points in the deleterious inflammatory cascade have been identified as possible sites for modulation. Dexamethasone attenuates tissue injury by inhibiting host mediators at several steps in the inflammatory process. Dexamethasone therapy initiated just before or simultaneously with the first parenteral antibiotic dose is recommended for infants older than 6 weeks of age and children with bacterial meningitis. A beneficial effect of steroid therapy administered 12 to 24 hours or more after the first dose of parenteral antibiotics is unlikely. The consistent finding of improved overall neurologic outcome in infants and children with bacterial meningitis caused by the usual meningeal pathogens treated with dexamethasone is the basis for this recommendation, provided that the caveats discussed above are observed.

AB - With improved understanding of the pathophysiology of bacterial meningitis, a number of points in the deleterious inflammatory cascade have been identified as possible sites for modulation. Dexamethasone attenuates tissue injury by inhibiting host mediators at several steps in the inflammatory process. Dexamethasone therapy initiated just before or simultaneously with the first parenteral antibiotic dose is recommended for infants older than 6 weeks of age and children with bacterial meningitis. A beneficial effect of steroid therapy administered 12 to 24 hours or more after the first dose of parenteral antibiotics is unlikely. The consistent finding of improved overall neurologic outcome in infants and children with bacterial meningitis caused by the usual meningeal pathogens treated with dexamethasone is the basis for this recommendation, provided that the caveats discussed above are observed.

UR - http://www.scopus.com/inward/record.url?scp=0028379233&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0028379233&partnerID=8YFLogxK

M3 - Article

C2 - 8196985

AN - SCOPUS:0028379233

VL - 23

SP - 82

EP - 88

JO - Pediatric Annals

JF - Pediatric Annals

SN - 0090-4481

IS - 2

ER -