Dextrorphan and dextromethorphan attenuate hypoxic injury in neuronal culture

Mark P. Goldberg; Phuong Chi Pham; Dennis W. Choi

doi:10.1016/0304-3940(87)90486-1

Dextrorphan and dextromethorphan attenuate hypoxic injury in neuronal culture

Mark P. Goldberg, Phuong Chi Pham, Dennis W. Choi

Research output: Contribution to journal › Article › peer-review

81 Scopus citations

Abstract

The dextrorotatory opioid derivatives, dextrorphan and dextromethorphan, can attenuate hypoxic injury in cortical cell cultures. This effect is concentration-dependent in the micromolar range, and not strongly stereospecific, as it can also be demonstrated with the levorotatory enantiomer of dextrorphan, levorphanol. The possibility that these clinically available compounds may have therapeutic utility in hypoxic or ischemic encephalopathy warrants further investigation.

Original language	English (US)
Pages (from-to)	11-15
Number of pages	5
Journal	Neuroscience letters
Volume	80
Issue number	1
DOIs	https://doi.org/10.1016/0304-3940(87)90486-1
State	Published - Sep 11 1987

Keywords

Cell culture
Cerebral cortex
Cerebral ischemia
Glutamate
Hypoxia
N-Methyl-d-aspartate
Opioid

ASJC Scopus subject areas

General Neuroscience

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10.1016/0304-3940(87)90486-1

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title = "Dextrorphan and dextromethorphan attenuate hypoxic injury in neuronal culture",

abstract = "The dextrorotatory opioid derivatives, dextrorphan and dextromethorphan, can attenuate hypoxic injury in cortical cell cultures. This effect is concentration-dependent in the micromolar range, and not strongly stereospecific, as it can also be demonstrated with the levorotatory enantiomer of dextrorphan, levorphanol. The possibility that these clinically available compounds may have therapeutic utility in hypoxic or ischemic encephalopathy warrants further investigation.",

keywords = "Cell culture, Cerebral cortex, Cerebral ischemia, Glutamate, Hypoxia, N-Methyl-d-aspartate, Opioid",

author = "Goldberg, {Mark P.} and Pham, {Phuong Chi} and Choi, {Dennis W.}",

note = "Funding Information: We thank Professor A. Goldstein and Dr. C. Weitz for helpful discussions, and Dr. Sorter at Hoffmann-La Roche for the kind gift of DX and LV. This research was supported by grants from the Wills Foundation and the Hereditary Disease Foundation. D.W.C. is a Hartford Foundation Fellow.",

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doi = "10.1016/0304-3940(87)90486-1",

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T1 - Dextrorphan and dextromethorphan attenuate hypoxic injury in neuronal culture

AU - Goldberg, Mark P.

AU - Pham, Phuong Chi

AU - Choi, Dennis W.

N1 - Funding Information: We thank Professor A. Goldstein and Dr. C. Weitz for helpful discussions, and Dr. Sorter at Hoffmann-La Roche for the kind gift of DX and LV. This research was supported by grants from the Wills Foundation and the Hereditary Disease Foundation. D.W.C. is a Hartford Foundation Fellow.

PY - 1987/9/11

Y1 - 1987/9/11

N2 - The dextrorotatory opioid derivatives, dextrorphan and dextromethorphan, can attenuate hypoxic injury in cortical cell cultures. This effect is concentration-dependent in the micromolar range, and not strongly stereospecific, as it can also be demonstrated with the levorotatory enantiomer of dextrorphan, levorphanol. The possibility that these clinically available compounds may have therapeutic utility in hypoxic or ischemic encephalopathy warrants further investigation.

AB - The dextrorotatory opioid derivatives, dextrorphan and dextromethorphan, can attenuate hypoxic injury in cortical cell cultures. This effect is concentration-dependent in the micromolar range, and not strongly stereospecific, as it can also be demonstrated with the levorotatory enantiomer of dextrorphan, levorphanol. The possibility that these clinically available compounds may have therapeutic utility in hypoxic or ischemic encephalopathy warrants further investigation.

KW - Cell culture

KW - Cerebral cortex

KW - Cerebral ischemia

KW - Glutamate

KW - Hypoxia

KW - N-Methyl-d-aspartate

KW - Opioid

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Dextrorphan and dextromethorphan attenuate hypoxic injury in neuronal culture

Abstract

Keywords

ASJC Scopus subject areas

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