Dextrorphan and dextromethorphan attenuate hypoxic injury in neuronal culture

Mark P. Goldberg, Phuong Chi Pham, Dennis W. Choi

Research output: Contribution to journalArticle

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Abstract

The dextrorotatory opioid derivatives, dextrorphan and dextromethorphan, can attenuate hypoxic injury in cortical cell cultures. This effect is concentration-dependent in the micromolar range, and not strongly stereospecific, as it can also be demonstrated with the levorotatory enantiomer of dextrorphan, levorphanol. The possibility that these clinically available compounds may have therapeutic utility in hypoxic or ischemic encephalopathy warrants further investigation.

Original languageEnglish (US)
Pages (from-to)11-15
Number of pages5
JournalNeuroscience Letters
Volume80
Issue number1
DOIs
StatePublished - Sep 11 1987

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Keywords

  • Cell culture
  • Cerebral cortex
  • Cerebral ischemia
  • Glutamate
  • Hypoxia
  • N-Methyl-d-aspartate
  • Opioid

ASJC Scopus subject areas

  • Neuroscience(all)

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