TY - JOUR
T1 - Diabetes mellitus and cardiovascular disease
T2 - Pandora's box has been opened
AU - Berry, Jarett D
AU - Keebler, Mary E.
AU - McGuire, Darren K
PY - 2004/8
Y1 - 2004/8
N2 - As a result of an aging, increasingly obese, and decreasingly physically active population, the global incidence and prevalence of type 2 diabetes mellitus (DM) is increasing. While little can be done to influence the contribution of aging to the increasing global prevalence of diabetes, opportunities abound to develop effective interventions with regard to diet, exercise and obesity to prevent type 2 DM and more importantly, diabetes-associated complications. The major cause of morbidity and mortality from diabetes is from atherosclerotic macrovascular disease - including peripheral, cerebrovascular, and coronary artery disease. The markedly increased risk for cardiovascular disease associated with diabetes compound medical and public health challenges in the face of the burgeoning global epidemic of diabetes and will inevitably strain healthcare resources. Although the cardiovascular benefits of glycemic control have yet to be clearly established, a number of therapeutic interventions improve cardiovascular risk among the high-risk cohort of patients with diabetes. The development of new strategies targeting both primary prevention of diabetes and the prevention of diabetic complications will remain important research and clinical objectives. Great advances are being made in the realm of diabetes and cardiovascular disease, and there is much optimism for the future.
AB - As a result of an aging, increasingly obese, and decreasingly physically active population, the global incidence and prevalence of type 2 diabetes mellitus (DM) is increasing. While little can be done to influence the contribution of aging to the increasing global prevalence of diabetes, opportunities abound to develop effective interventions with regard to diet, exercise and obesity to prevent type 2 DM and more importantly, diabetes-associated complications. The major cause of morbidity and mortality from diabetes is from atherosclerotic macrovascular disease - including peripheral, cerebrovascular, and coronary artery disease. The markedly increased risk for cardiovascular disease associated with diabetes compound medical and public health challenges in the face of the burgeoning global epidemic of diabetes and will inevitably strain healthcare resources. Although the cardiovascular benefits of glycemic control have yet to be clearly established, a number of therapeutic interventions improve cardiovascular risk among the high-risk cohort of patients with diabetes. The development of new strategies targeting both primary prevention of diabetes and the prevention of diabetic complications will remain important research and clinical objectives. Great advances are being made in the realm of diabetes and cardiovascular disease, and there is much optimism for the future.
KW - Cardiovascular disease
KW - Diabetes mellitus
KW - Evidence-based medicine
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U2 - 10.1007/s00059-004-2605-1
DO - 10.1007/s00059-004-2605-1
M3 - Review article
C2 - 15340730
AN - SCOPUS:4444305513
SN - 0340-9937
VL - 29
SP - 456
EP - 462
JO - Herz
JF - Herz
IS - 5
ER -