Diabetic cardiomyopathy: Mechanisms and therapeutic targets

Pavan K. Battiprolu, Thomas G. Gillette, Zhao Wang, Sergio Lavandero, Joseph A Hill

Research output: Contribution to journalReview article

97 Scopus citations

Abstract

The incidence and prevalence of diabetes mellitus are each increasing rapidly in our society. The majority of patients with diabetes succumb ultimately to heart disease, much of which stems from atherosclerotic disease and hypertension. However, cardiomyopathy can develop independent of elevated blood pressure or coronary artery disease, a process termed diabetic cardiomyopathy. This disorder is a complex diabetes-associated process characterized by significant changes in the physiology, structure, and mechanical function of the heart. Here, we review recently derived insights into mechanisms and molecular events involved in the pathogenesis of diabetic cardiomyopathy.

Original languageEnglish (US)
Pages (from-to)e135-e143
JournalDrug Discovery Today: Disease Mechanisms
Volume7
Issue number2
DOIs
StatePublished - Jun 1 2010

ASJC Scopus subject areas

  • Molecular Medicine
  • Drug Discovery

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