TY - JOUR
T1 - Diabetic cardiomyopathy
T2 - Mechanisms and therapeutic targets
AU - Battiprolu, Pavan K.
AU - Gillette, Thomas G.
AU - Wang, Zhao
AU - Lavandero, Sergio
AU - Hill, Joseph A
N1 - Funding Information:
This work was supported by grants from the NIH (HL-075173, JAH; HL-080144, JAH; HL-090842, JAH), AHA (0640084N, JAH), ADA (7-08-MN-21-ADA, JAH), the AHA-Jon Holden DeHaan Foundation (0970518N, JAH), and the Fondo Nacional de Desarrollo Cientifico y Tecnologico : FONDECYT 1080436 and FONDAP 15010006 (SL).
PY - 2010/6
Y1 - 2010/6
N2 - The incidence and prevalence of diabetes mellitus are each increasing rapidly in our society. The majority of patients with diabetes succumb ultimately to heart disease, much of which stems from atherosclerotic disease and hypertension. However, cardiomyopathy can develop independent of elevated blood pressure or coronary artery disease, a process termed diabetic cardiomyopathy. This disorder is a complex diabetes-associated process characterized by significant changes in the physiology, structure, and mechanical function of the heart. Here, we review recently derived insights into mechanisms and molecular events involved in the pathogenesis of diabetic cardiomyopathy.
AB - The incidence and prevalence of diabetes mellitus are each increasing rapidly in our society. The majority of patients with diabetes succumb ultimately to heart disease, much of which stems from atherosclerotic disease and hypertension. However, cardiomyopathy can develop independent of elevated blood pressure or coronary artery disease, a process termed diabetic cardiomyopathy. This disorder is a complex diabetes-associated process characterized by significant changes in the physiology, structure, and mechanical function of the heart. Here, we review recently derived insights into mechanisms and molecular events involved in the pathogenesis of diabetic cardiomyopathy.
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U2 - 10.1016/j.ddmec.2010.08.001
DO - 10.1016/j.ddmec.2010.08.001
M3 - Review article
C2 - 21274425
AN - SCOPUS:78649326868
SN - 1740-6765
VL - 7
SP - e135-e143
JO - Drug Discovery Today: Disease Mechanisms
JF - Drug Discovery Today: Disease Mechanisms
IS - 2
ER -