Diabetic cardiomyopathy: Mechanisms and therapeutic targets

Pavan K. Battiprolu, Thomas G. Gillette, Zhao Wang, Sergio Lavandero, Joseph A Hill

Research output: Contribution to journalArticle

88 Citations (Scopus)

Abstract

The incidence and prevalence of diabetes mellitus are each increasing rapidly in our society. The majority of patients with diabetes succumb ultimately to heart disease, much of which stems from atherosclerotic disease and hypertension. However, cardiomyopathy can develop independent of elevated blood pressure or coronary artery disease, a process termed diabetic cardiomyopathy. This disorder is a complex diabetes-associated process characterized by significant changes in the physiology, structure, and mechanical function of the heart. Here, we review recently derived insights into mechanisms and molecular events involved in the pathogenesis of diabetic cardiomyopathy.

Original languageEnglish (US)
JournalDrug Discovery Today: Disease Mechanisms
Volume7
Issue number2
DOIs
StatePublished - Jun 2010

Fingerprint

Diabetic Cardiomyopathies
Cardiomyopathies
Coronary Artery Disease
Heart Diseases
Diabetes Mellitus
Blood Pressure
Hypertension
Incidence
Therapeutics

ASJC Scopus subject areas

  • Drug Discovery
  • Molecular Medicine

Cite this

Diabetic cardiomyopathy : Mechanisms and therapeutic targets. / Battiprolu, Pavan K.; Gillette, Thomas G.; Wang, Zhao; Lavandero, Sergio; Hill, Joseph A.

In: Drug Discovery Today: Disease Mechanisms, Vol. 7, No. 2, 06.2010.

Research output: Contribution to journalArticle

Battiprolu, Pavan K. ; Gillette, Thomas G. ; Wang, Zhao ; Lavandero, Sergio ; Hill, Joseph A. / Diabetic cardiomyopathy : Mechanisms and therapeutic targets. In: Drug Discovery Today: Disease Mechanisms. 2010 ; Vol. 7, No. 2.
@article{811202e943044fec990f063a389cf763,
title = "Diabetic cardiomyopathy: Mechanisms and therapeutic targets",
abstract = "The incidence and prevalence of diabetes mellitus are each increasing rapidly in our society. The majority of patients with diabetes succumb ultimately to heart disease, much of which stems from atherosclerotic disease and hypertension. However, cardiomyopathy can develop independent of elevated blood pressure or coronary artery disease, a process termed diabetic cardiomyopathy. This disorder is a complex diabetes-associated process characterized by significant changes in the physiology, structure, and mechanical function of the heart. Here, we review recently derived insights into mechanisms and molecular events involved in the pathogenesis of diabetic cardiomyopathy.",
author = "Battiprolu, {Pavan K.} and Gillette, {Thomas G.} and Zhao Wang and Sergio Lavandero and Hill, {Joseph A}",
year = "2010",
month = "6",
doi = "10.1016/j.ddmec.2010.08.001",
language = "English (US)",
volume = "7",
journal = "Drug Discovery Today: Disease Mechanisms",
issn = "1740-6765",
publisher = "Elsevier Limited",
number = "2",

}

TY - JOUR

T1 - Diabetic cardiomyopathy

T2 - Mechanisms and therapeutic targets

AU - Battiprolu, Pavan K.

AU - Gillette, Thomas G.

AU - Wang, Zhao

AU - Lavandero, Sergio

AU - Hill, Joseph A

PY - 2010/6

Y1 - 2010/6

N2 - The incidence and prevalence of diabetes mellitus are each increasing rapidly in our society. The majority of patients with diabetes succumb ultimately to heart disease, much of which stems from atherosclerotic disease and hypertension. However, cardiomyopathy can develop independent of elevated blood pressure or coronary artery disease, a process termed diabetic cardiomyopathy. This disorder is a complex diabetes-associated process characterized by significant changes in the physiology, structure, and mechanical function of the heart. Here, we review recently derived insights into mechanisms and molecular events involved in the pathogenesis of diabetic cardiomyopathy.

AB - The incidence and prevalence of diabetes mellitus are each increasing rapidly in our society. The majority of patients with diabetes succumb ultimately to heart disease, much of which stems from atherosclerotic disease and hypertension. However, cardiomyopathy can develop independent of elevated blood pressure or coronary artery disease, a process termed diabetic cardiomyopathy. This disorder is a complex diabetes-associated process characterized by significant changes in the physiology, structure, and mechanical function of the heart. Here, we review recently derived insights into mechanisms and molecular events involved in the pathogenesis of diabetic cardiomyopathy.

UR - http://www.scopus.com/inward/record.url?scp=78649326868&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=78649326868&partnerID=8YFLogxK

U2 - 10.1016/j.ddmec.2010.08.001

DO - 10.1016/j.ddmec.2010.08.001

M3 - Article

C2 - 21274425

AN - SCOPUS:78649326868

VL - 7

JO - Drug Discovery Today: Disease Mechanisms

JF - Drug Discovery Today: Disease Mechanisms

SN - 1740-6765

IS - 2

ER -