Diabetic foot osteomyelitis: Bone markers and treatment outcomes

Humaa A. Nyazee, Kristina M. Finney, Molly Sarikonda, Dwight A. Towler, Jeffrey E. Johnson, Hilary M. Babcock

Research output: Contribution to journalArticle

7 Scopus citations


Aims: Novel bone turnover markers could help with the diagnosis and monitoring of osteomyelitis patients. We compared levels of two bone turnover markers, serum amino-terminal telopeptides (NTx) and bone alkaline phosphatase (BAP), in diabetic patients with and without osteomyelitis. Methods: Matched case-control study was conducted with diabetic patients with and without osteomyelitis. Cases not undergoing immediate amputation were followed with repeat measurements after osteomyelitis treatment and for outcome determination. Results: Analysis included 54 subjects, 27 cases and 27 controls. Median BAP levels were similar between cases and controls at enrollment (p= .55) as were median NTx levels (p= .43). Cases with follow-up data (n=18) had similar bone marker levels at enrollment and 6 weeks. No significant differences in BAP or NTx levels at enrollment or follow-up were seen between cases with poor versus favorable outcomes. Conclusions: No differences in NTx or BAP levels were seen between cases and controls. Cases with follow-up data had similar levels at enrollment and 6 weeks. Lack of difference may be due to small sample size, small areas of bone involved in foot osteomyelitis, or limitations of these specific markers. More research is needed.

Original languageEnglish (US)
Pages (from-to)411-417
Number of pages7
JournalDiabetes Research and Clinical Practice
Issue number3
StatePublished - Sep 1 2012



  • Bone markers
  • Diabetic foot ulcers
  • Osteomyelitis
  • Treatment outcomes

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

Cite this