Abstract
Glucose uptake into pancreatic β cells by means of the glucose transporter GLUT-2, which has a high Michaelis constant, is essential for the normal insulin secretory response to hyperglycemia. In both autoimmune and nonautoimmune diabetes, this glucose transport is reduced as a consequence of down-regulation of the normal β-cell transporter. In autoimmune diabetes, circulating immunoglobulins can further impair this glucose transport by inhibiting functionally intact transporters. Insights into mechanisms of the unresponsiveness of cells to hyperglycemia may improve the management and prevention of diabetes.
Original language | English (US) |
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Pages (from-to) | 1200-1205 |
Number of pages | 6 |
Journal | Science |
Volume | 251 |
Issue number | 4998 |
State | Published - Mar 8 1991 |
ASJC Scopus subject areas
- General