TY - JOUR
T1 - Diagnosis and differential diagnosis of hepatic graft versus host disease (GVHD)
AU - Matsukuma, Karen E.
AU - Wei, Dongguang
AU - Sun, Kai
AU - Ramsamooj, Rajendra
AU - Chen, Mingyi
N1 - Funding Information:
This work was supported by Collaborative Institutional Research Grant Pilot Funding for Investigators in Oncology UC Davis (MC), National Natural Science Foundation of China (No. 81273259, No. 81471589, KS). DW was sponsored by Edwin Everest Foundation Fellowship.
Publisher Copyright:
© Journal of Gastrointestinal Oncology. All rights reserved.
PY - 2016/4/1
Y1 - 2016/4/1
N2 - Graft versus host disease (GVHD) is a common complication following allogeneic hematopoietic cell transplantation (HCT) that typically manifests as injury to the skin, gastrointestinal mucosa, and liver. In some cases, hepatic GVHD may be histologically indistinguishable from other disorders such as infection and drug-induced liver injury (DILI). Additionally, clinical signs and symptoms are frequently confounded by the superimposed effects of pretransplant chemoradiotherapy, immunotherapy (IT) (targeted to the underlying malignancy), GVHD prophylaxis, and infection. Thus, careful attention to and correlation with clinical findings, laboratory values, and histologic features is essential for diagnosis. This review, aimed at the practicing pathologist, will discuss current clinical and histologic criteria for GVHD, the approach to diagnosis of hepatic GVHD, and features helpful for distinguishing it from other entities in the differential diagnosis.
AB - Graft versus host disease (GVHD) is a common complication following allogeneic hematopoietic cell transplantation (HCT) that typically manifests as injury to the skin, gastrointestinal mucosa, and liver. In some cases, hepatic GVHD may be histologically indistinguishable from other disorders such as infection and drug-induced liver injury (DILI). Additionally, clinical signs and symptoms are frequently confounded by the superimposed effects of pretransplant chemoradiotherapy, immunotherapy (IT) (targeted to the underlying malignancy), GVHD prophylaxis, and infection. Thus, careful attention to and correlation with clinical findings, laboratory values, and histologic features is essential for diagnosis. This review, aimed at the practicing pathologist, will discuss current clinical and histologic criteria for GVHD, the approach to diagnosis of hepatic GVHD, and features helpful for distinguishing it from other entities in the differential diagnosis.
KW - Drug-induced liver injury (DILI)
KW - Graft versus host disease (GVHD)
KW - Hematopoietic cell transplantation (HCT)
KW - Hepatic lymphoma
KW - Immunotherapy (IT)
KW - Post-transplant lymphoproliferative disorder (PTLD)
KW - Veno-occlusive hepatic disease
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U2 - 10.3978/j.issn.2078-6891.2015.036
DO - 10.3978/j.issn.2078-6891.2015.036
M3 - Review article
C2 - 27034810
AN - SCOPUS:84995772463
SN - 2078-6891
VL - 7
SP - S21-S31
JO - Journal of Gastrointestinal Oncology
JF - Journal of Gastrointestinal Oncology
ER -