Diagnosis and treatment of hyperkalemia

Biff F. Palmer, Deborah J. Clegg

Research output: Contribution to journalReview article

6 Citations (Scopus)

Abstract

Hyperkalemia results either from the shift of potassium out of cells or from abnormal renal potassium excretion. Cell shift leads to transient increases in the plasma potassium concentration, whereas decreased renal excretion of potassium leads to sustained hyperkalemia. Impairments in renal potassium excretion can be the result of reduced sodium delivery to the distal nephron, decreased mineralocorticoid level or activity, or abnormalities in the cortical collecting duct. In some instances, all 3 of these perturbations are present. Excessive intake of potassium can cause hyperkalemia but usually in the setting of impaired renal function. We discuss the clinical manifestations of hyperkalemia and outline an approach to its diagnosis and treatment.

Original languageEnglish (US)
Pages (from-to)934-942
Number of pages9
JournalCleveland Clinic Journal of Medicine
Volume84
Issue number12
DOIs
StatePublished - Jan 1 2017

Fingerprint

Hyperkalemia
Potassium
Mineralocorticoids
Nephrons
Sodium
Kidney
Renal Elimination

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Diagnosis and treatment of hyperkalemia. / Palmer, Biff F.; Clegg, Deborah J.

In: Cleveland Clinic Journal of Medicine, Vol. 84, No. 12, 01.01.2017, p. 934-942.

Research output: Contribution to journalReview article

Palmer, Biff F. ; Clegg, Deborah J. / Diagnosis and treatment of hyperkalemia. In: Cleveland Clinic Journal of Medicine. 2017 ; Vol. 84, No. 12. pp. 934-942.
@article{6f04fda92cb94225b10f02d01079762d,
title = "Diagnosis and treatment of hyperkalemia",
abstract = "Hyperkalemia results either from the shift of potassium out of cells or from abnormal renal potassium excretion. Cell shift leads to transient increases in the plasma potassium concentration, whereas decreased renal excretion of potassium leads to sustained hyperkalemia. Impairments in renal potassium excretion can be the result of reduced sodium delivery to the distal nephron, decreased mineralocorticoid level or activity, or abnormalities in the cortical collecting duct. In some instances, all 3 of these perturbations are present. Excessive intake of potassium can cause hyperkalemia but usually in the setting of impaired renal function. We discuss the clinical manifestations of hyperkalemia and outline an approach to its diagnosis and treatment.",
author = "Palmer, {Biff F.} and Clegg, {Deborah J.}",
year = "2017",
month = "1",
day = "1",
doi = "10.3949/ccjm.84a.17056",
language = "English (US)",
volume = "84",
pages = "934--942",
journal = "Cleveland Clinic Journal of Medicine",
issn = "0891-1150",
publisher = "Cleveland Clinic Educational Foundation",
number = "12",

}

TY - JOUR

T1 - Diagnosis and treatment of hyperkalemia

AU - Palmer, Biff F.

AU - Clegg, Deborah J.

PY - 2017/1/1

Y1 - 2017/1/1

N2 - Hyperkalemia results either from the shift of potassium out of cells or from abnormal renal potassium excretion. Cell shift leads to transient increases in the plasma potassium concentration, whereas decreased renal excretion of potassium leads to sustained hyperkalemia. Impairments in renal potassium excretion can be the result of reduced sodium delivery to the distal nephron, decreased mineralocorticoid level or activity, or abnormalities in the cortical collecting duct. In some instances, all 3 of these perturbations are present. Excessive intake of potassium can cause hyperkalemia but usually in the setting of impaired renal function. We discuss the clinical manifestations of hyperkalemia and outline an approach to its diagnosis and treatment.

AB - Hyperkalemia results either from the shift of potassium out of cells or from abnormal renal potassium excretion. Cell shift leads to transient increases in the plasma potassium concentration, whereas decreased renal excretion of potassium leads to sustained hyperkalemia. Impairments in renal potassium excretion can be the result of reduced sodium delivery to the distal nephron, decreased mineralocorticoid level or activity, or abnormalities in the cortical collecting duct. In some instances, all 3 of these perturbations are present. Excessive intake of potassium can cause hyperkalemia but usually in the setting of impaired renal function. We discuss the clinical manifestations of hyperkalemia and outline an approach to its diagnosis and treatment.

UR - http://www.scopus.com/inward/record.url?scp=85036543071&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85036543071&partnerID=8YFLogxK

U2 - 10.3949/ccjm.84a.17056

DO - 10.3949/ccjm.84a.17056

M3 - Review article

VL - 84

SP - 934

EP - 942

JO - Cleveland Clinic Journal of Medicine

JF - Cleveland Clinic Journal of Medicine

SN - 0891-1150

IS - 12

ER -