Diagnosis of alcohol misuse and alcoholic liver disease among patients in the medical emergency admission service of a large urban hospital in Sub-Saharan Africa; a cross sectional study

Christopher Kenneth Opio, Emmanuel Seremba, Ponciano Ocama, Rejani Lalitha, Magid Kagimu, William Martens Lee

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Introduction: Uganda is among the top ten consumers of alcohol worldwide though there is little data on alcohol related liver disease. We describe alcohol use, alcohol misuse, and alcoholic liver disease among adults at the emergency admission service of a large urban hospital in Uganda. Methods: All adults who consented were prospectively evaluated for alcohol use by inquiry and alcohol misuse by the "Cutting down, Annoyance, Guilt and Eye-opener- CAGE" questionnaire. Alcohol related hepatocellular liver injury was assessed using aspartate aminotransferase, and alanine aminotransferase levels. A combination of CAGE score ≥2 and De Ritis ratio ≥2 defined alcoholic liver disease (ALD). Human Immunodeficiency Virus (HIV), and viral hepatitis B and C serologies were evaluated in all the patients. Descriptive and inferential statistics were generated to answer our research questions. Results: Three hundred and eighty individuals consented and participated in the study. Among these, 46.8% acknowledged use of alcohol while 21% and 10% met the study definition of alcoholic misuse and alcoholic liver disease respectively. Both alcohol misuse and alcoholic liver disease was significantly associated (p-value ≤ 0.05) with male gender, region of origin, number of life time sexual partners and serum albumin below 3.5 mg/dl after univariate and multivariate analysis. Conclusion: Alcohol misuse and alcoholic liver disease is frequent in this medical emergency unit. Our study suggests a link between alcohol misuse or alcoholic liver disease and male gender, region of origin, number of sexual partners, and serum albumin below 3.5mg/dl.

Original languageEnglish (US)
Article number23
JournalPan African Medical Journal
Volume15
DOIs
StatePublished - 2013

Fingerprint

Alcoholic Liver Diseases
Africa South of the Sahara
Urban Hospitals
Emergency Medical Services
Cross-Sectional Studies
Alcohols
Uganda
Sexual Partners
Serum Albumin
Guilt
Serology
Hepatitis C
Aspartate Aminotransferases
Hepatitis B
Alanine Transaminase
Hospital Emergency Service
Liver Diseases
Emergencies
Multivariate Analysis
HIV

Keywords

  • Alanine aminotransferase
  • Alcohol misuse
  • Alcohol use
  • Alcoholic liver disease
  • Aspartate aminotransferase
  • CAGE questionnaire
  • De Ritis ratio

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Diagnosis of alcohol misuse and alcoholic liver disease among patients in the medical emergency admission service of a large urban hospital in Sub-Saharan Africa; a cross sectional study. / Opio, Christopher Kenneth; Seremba, Emmanuel; Ocama, Ponciano; Lalitha, Rejani; Kagimu, Magid; Lee, William Martens.

In: Pan African Medical Journal, Vol. 15, 23, 2013.

Research output: Contribution to journalArticle

@article{85ddaadc9b384005842e7f4fe7a6cf3c,
title = "Diagnosis of alcohol misuse and alcoholic liver disease among patients in the medical emergency admission service of a large urban hospital in Sub-Saharan Africa; a cross sectional study",
abstract = "Introduction: Uganda is among the top ten consumers of alcohol worldwide though there is little data on alcohol related liver disease. We describe alcohol use, alcohol misuse, and alcoholic liver disease among adults at the emergency admission service of a large urban hospital in Uganda. Methods: All adults who consented were prospectively evaluated for alcohol use by inquiry and alcohol misuse by the {"}Cutting down, Annoyance, Guilt and Eye-opener- CAGE{"} questionnaire. Alcohol related hepatocellular liver injury was assessed using aspartate aminotransferase, and alanine aminotransferase levels. A combination of CAGE score ≥2 and De Ritis ratio ≥2 defined alcoholic liver disease (ALD). Human Immunodeficiency Virus (HIV), and viral hepatitis B and C serologies were evaluated in all the patients. Descriptive and inferential statistics were generated to answer our research questions. Results: Three hundred and eighty individuals consented and participated in the study. Among these, 46.8{\%} acknowledged use of alcohol while 21{\%} and 10{\%} met the study definition of alcoholic misuse and alcoholic liver disease respectively. Both alcohol misuse and alcoholic liver disease was significantly associated (p-value ≤ 0.05) with male gender, region of origin, number of life time sexual partners and serum albumin below 3.5 mg/dl after univariate and multivariate analysis. Conclusion: Alcohol misuse and alcoholic liver disease is frequent in this medical emergency unit. Our study suggests a link between alcohol misuse or alcoholic liver disease and male gender, region of origin, number of sexual partners, and serum albumin below 3.5mg/dl.",
keywords = "Alanine aminotransferase, Alcohol misuse, Alcohol use, Alcoholic liver disease, Aspartate aminotransferase, CAGE questionnaire, De Ritis ratio",
author = "Opio, {Christopher Kenneth} and Emmanuel Seremba and Ponciano Ocama and Rejani Lalitha and Magid Kagimu and Lee, {William Martens}",
year = "2013",
doi = "10.11604/pamj.2013.15.23.2040",
language = "English (US)",
volume = "15",
journal = "Pan African Medical Journal",
issn = "1937-8688",
publisher = "Pan African Medical Journal",

}

TY - JOUR

T1 - Diagnosis of alcohol misuse and alcoholic liver disease among patients in the medical emergency admission service of a large urban hospital in Sub-Saharan Africa; a cross sectional study

AU - Opio, Christopher Kenneth

AU - Seremba, Emmanuel

AU - Ocama, Ponciano

AU - Lalitha, Rejani

AU - Kagimu, Magid

AU - Lee, William Martens

PY - 2013

Y1 - 2013

N2 - Introduction: Uganda is among the top ten consumers of alcohol worldwide though there is little data on alcohol related liver disease. We describe alcohol use, alcohol misuse, and alcoholic liver disease among adults at the emergency admission service of a large urban hospital in Uganda. Methods: All adults who consented were prospectively evaluated for alcohol use by inquiry and alcohol misuse by the "Cutting down, Annoyance, Guilt and Eye-opener- CAGE" questionnaire. Alcohol related hepatocellular liver injury was assessed using aspartate aminotransferase, and alanine aminotransferase levels. A combination of CAGE score ≥2 and De Ritis ratio ≥2 defined alcoholic liver disease (ALD). Human Immunodeficiency Virus (HIV), and viral hepatitis B and C serologies were evaluated in all the patients. Descriptive and inferential statistics were generated to answer our research questions. Results: Three hundred and eighty individuals consented and participated in the study. Among these, 46.8% acknowledged use of alcohol while 21% and 10% met the study definition of alcoholic misuse and alcoholic liver disease respectively. Both alcohol misuse and alcoholic liver disease was significantly associated (p-value ≤ 0.05) with male gender, region of origin, number of life time sexual partners and serum albumin below 3.5 mg/dl after univariate and multivariate analysis. Conclusion: Alcohol misuse and alcoholic liver disease is frequent in this medical emergency unit. Our study suggests a link between alcohol misuse or alcoholic liver disease and male gender, region of origin, number of sexual partners, and serum albumin below 3.5mg/dl.

AB - Introduction: Uganda is among the top ten consumers of alcohol worldwide though there is little data on alcohol related liver disease. We describe alcohol use, alcohol misuse, and alcoholic liver disease among adults at the emergency admission service of a large urban hospital in Uganda. Methods: All adults who consented were prospectively evaluated for alcohol use by inquiry and alcohol misuse by the "Cutting down, Annoyance, Guilt and Eye-opener- CAGE" questionnaire. Alcohol related hepatocellular liver injury was assessed using aspartate aminotransferase, and alanine aminotransferase levels. A combination of CAGE score ≥2 and De Ritis ratio ≥2 defined alcoholic liver disease (ALD). Human Immunodeficiency Virus (HIV), and viral hepatitis B and C serologies were evaluated in all the patients. Descriptive and inferential statistics were generated to answer our research questions. Results: Three hundred and eighty individuals consented and participated in the study. Among these, 46.8% acknowledged use of alcohol while 21% and 10% met the study definition of alcoholic misuse and alcoholic liver disease respectively. Both alcohol misuse and alcoholic liver disease was significantly associated (p-value ≤ 0.05) with male gender, region of origin, number of life time sexual partners and serum albumin below 3.5 mg/dl after univariate and multivariate analysis. Conclusion: Alcohol misuse and alcoholic liver disease is frequent in this medical emergency unit. Our study suggests a link between alcohol misuse or alcoholic liver disease and male gender, region of origin, number of sexual partners, and serum albumin below 3.5mg/dl.

KW - Alanine aminotransferase

KW - Alcohol misuse

KW - Alcohol use

KW - Alcoholic liver disease

KW - Aspartate aminotransferase

KW - CAGE questionnaire

KW - De Ritis ratio

UR - http://www.scopus.com/inward/record.url?scp=84887492561&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84887492561&partnerID=8YFLogxK

U2 - 10.11604/pamj.2013.15.23.2040

DO - 10.11604/pamj.2013.15.23.2040

M3 - Article

VL - 15

JO - Pan African Medical Journal

JF - Pan African Medical Journal

SN - 1937-8688

M1 - 23

ER -