TY - JOUR
T1 - Diagnostic and Therapeutic Potential of Exosomes in Cancer
T2 - The Beginning of a New Tale?
AU - Mirzaei, Hamed
AU - Sahebkar, Amirhossein
AU - Jaafari, Mahmoud Reza
AU - Goodarzi, Mohammad
AU - Mirzaei, Hamid Reza
N1 - Publisher Copyright:
© 2016 Wiley Periodicals, Inc.
PY - 2017/12
Y1 - 2017/12
N2 - Exosomes have emerged as one of the main players in intercellular communication. These small nano-sized particles have many roles in various physiological pathways in normal and abnormal cells. Exosomes can carry various cargos such as proteins, mRNAs, and miRNAs to recipient cells. Uptake of exosomes and their cargo can induce and/or inhibit different cellular and molecular pathways that lead to the alteration of cell behavior. Multiple lines of evidence have indicated that exosomes released from cancer cells can effect development of cancer in different stages. These particles and their cargo could regulate different processes such as tumor growth, metastasis, drug resistance, angiogenesis, and immune system functioning. It has been observed that exosomes can be used as potential diagnostic biomarkers in various cancer types. Moreover, some studies have used these particles as biological vehicles for delivery of various drugs such as doxorubicin, siRNAs, and miRNAs. Here, we summarized the findings on the role of exosomes in different pathological processes involved in cancer. Moreover, application of these particles as diagnostic and therapeutic biomarkers in different types of cancers is discussed. J. Cell. Physiol. 232: 3251–3260, 2017.
AB - Exosomes have emerged as one of the main players in intercellular communication. These small nano-sized particles have many roles in various physiological pathways in normal and abnormal cells. Exosomes can carry various cargos such as proteins, mRNAs, and miRNAs to recipient cells. Uptake of exosomes and their cargo can induce and/or inhibit different cellular and molecular pathways that lead to the alteration of cell behavior. Multiple lines of evidence have indicated that exosomes released from cancer cells can effect development of cancer in different stages. These particles and their cargo could regulate different processes such as tumor growth, metastasis, drug resistance, angiogenesis, and immune system functioning. It has been observed that exosomes can be used as potential diagnostic biomarkers in various cancer types. Moreover, some studies have used these particles as biological vehicles for delivery of various drugs such as doxorubicin, siRNAs, and miRNAs. Here, we summarized the findings on the role of exosomes in different pathological processes involved in cancer. Moreover, application of these particles as diagnostic and therapeutic biomarkers in different types of cancers is discussed. J. Cell. Physiol. 232: 3251–3260, 2017.
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U2 - 10.1002/jcp.25739
DO - 10.1002/jcp.25739
M3 - Review article
C2 - 27966794
AN - SCOPUS:85018699233
SN - 0021-9541
VL - 232
SP - 3251
EP - 3260
JO - Journal of cellular physiology
JF - Journal of cellular physiology
IS - 12
ER -