Diagnostic and therapeutic strategies for management of autoimmune encephalopathies

Divyanshu Dubey, Kyle Blackburn, Benjamin Greenberg, Olaf Stuve, Steven Vernino

Research output: Contribution to journalReview articlepeer-review

16 Scopus citations

Abstract

Introduction: The understanding of the etio-pathogenesis of autoimmune encephalopathy syndromes has grown significantly in recent years. These are potentially reversible conditions, with variable clinical presentation and potential dramatic response to immunotherapy. Areas covered: In this article we review various diagnostic techniques and therapeutic options for management of autoimmune encephalopathy. We also review medication adverse effects and monitoring strategies. Expert commentary: Early diagnosis and immunomodulatory treatment remains the cornerstone of management, to halt the underlying neuro-inflammatory process and prevent permanent neuronal injury. The availability of serological testing and various imaging modalities has further improved detection of these immune-mediated neurological disorders. Understanding the mechanisms and potential adverse effects of immunomodulatory therapies will help physicians to choose the most favorable therapeutic strategy for each patient.

Original languageEnglish (US)
Pages (from-to)937-949
Number of pages13
JournalExpert Review of Neurotherapeutics
Volume16
Issue number8
DOIs
StatePublished - Aug 2 2016

Keywords

  • autoimmune disease
  • Encephalitis
  • epilepsy
  • immunotherapy
  • limbic encephalitis
  • paraneoplastic

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Neurology
  • Pharmacology (medical)

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