Diagnostic assays for identification of microorganisms and antimicrobial resistance determinants directly from positive blood culture broth

Morgan A. Pence, Erin McElvania TeKippe, Carey Ann D Burnham

Research output: Contribution to journalReview article

18 Scopus citations

Abstract

The detection of blood stream infections is one of the most important functions of the clinical microbiology laboratory. Sepsis is a clinical emergency, and mortality increases if commencement of appropriate antimicrobial therapy is delayed. Automated blood culture systems are the most sensitive approach for detection of the causative agent of sepsis. Several laboratory methods have been developed to expedite identification of organisms directly from positive blood culture broth. The principle and analytical performance characteristics of these methods are described in this review.

Original languageEnglish (US)
Pages (from-to)651-684
Number of pages34
JournalClinics in laboratory medicine
Volume33
Issue number3
DOIs
StatePublished - Sep 1 2013

Keywords

  • Bacteremia
  • Blood culture
  • MRSA
  • Molecular diagnostics
  • Rapid pathogen detection
  • Staphylococcus aureus

ASJC Scopus subject areas

  • Clinical Biochemistry
  • Biochemistry, medical

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