Dibutyryl cAMP-induced protein changes in differentiating mouse neuroblastoma cells

N. Prashad, B. Wischmeyer, C. Evetts, F. Baskin, R. Rosenberg

Research output: Contribution to journalArticlepeer-review

24 Scopus citations

Abstract

Proteins from mouse neuroblastoma cells treated with dibutyryl adenosine-3′,5′-monophosphate (B2cAMP) were analyzed by high resolution, two-dimensional gel electrophoresic. Quantitative changes in proteins and charge modifications of proteins apparently induced B2cAMP were detected by isoelectric focusing. Some proteins appeared to be modified and one protein was increased 7- to 8-fold in cells treated with B2cAMP. Since neuroblastoma cells differentiate when treated with B2cAMP, understanding the protein changes induced by B2cAMP may help to understand cellular differentiation in neural tissue.

Original languageEnglish (US)
Pages (from-to)147-157
Number of pages11
JournalCell Differentiation
Volume6
Issue number2
DOIs
StatePublished - Aug 1977

ASJC Scopus subject areas

  • Developmental Biology

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