TY - JOUR
T1 - Dietary control of chromatin
AU - Huang, Zhiguang
AU - Cai, Ling
AU - Tu, Benjamin P.
N1 - Publisher Copyright:
© 2015 Elsevier Ltd.
PY - 2015/6/1
Y1 - 2015/6/1
N2 - Organisms must be able to rapidly alter gene expression in response to changes in their nutrient environment. This review summarizes evidence that epigenetic modifications of chromatin depend on particular metabolites of intermediary metabolism, enabling the facile regulation of gene expression in tune with metabolic state. Nutritional or dietary control of chromatin is an often-overlooked, yet fundamental regulatory mechanism directly linked to human physiology. Nutrient-sensitive epigenetic marks are dynamic, suggesting rapid turnover, and may have functions beyond the regulation of gene transcription, including pH regulation and as carbon sources in cancer cells.
AB - Organisms must be able to rapidly alter gene expression in response to changes in their nutrient environment. This review summarizes evidence that epigenetic modifications of chromatin depend on particular metabolites of intermediary metabolism, enabling the facile regulation of gene expression in tune with metabolic state. Nutritional or dietary control of chromatin is an often-overlooked, yet fundamental regulatory mechanism directly linked to human physiology. Nutrient-sensitive epigenetic marks are dynamic, suggesting rapid turnover, and may have functions beyond the regulation of gene transcription, including pH regulation and as carbon sources in cancer cells.
UR - http://www.scopus.com/inward/record.url?scp=84934924728&partnerID=8YFLogxK
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U2 - 10.1016/j.ceb.2015.05.004
DO - 10.1016/j.ceb.2015.05.004
M3 - Review article
C2 - 26094239
AN - SCOPUS:84934924728
SN - 0955-0674
VL - 34
SP - 69
EP - 74
JO - Current Opinion in Cell Biology
JF - Current Opinion in Cell Biology
ER -