Dietary factors and pediatric multiple sclerosis: A case-control study

for the US Network of Pediatric Multiple Sclerosis Centers

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Background: The role of diet in multiple sclerosis (MS) is largely uncharacterized, particularly as it pertains to pediatric-onset disease. Objective: To determine the association between dietary factors and MS in children. Methods: Pediatric MS patients and controls were recruited from 16 US centers (MS or clinically isolated syndrome onset before age 18, <4 years from symptom onset and at least 2 silent lesions on magnetic resonance imaging). The validated Block Kids Food Screener questionnaire was administered 2011–2016. Chi-squared test compared categorical variables, Kruskal–Wallis test compared continuous variables, and multivariable logistic regression analysis was performed. Results: In total, 312 cases and 456 controls were included (mean ages 15.1 and 14.4 years). In unadjusted analyses, there was no difference in intake of fats, proteins, carbohydrates, sugars, fruits, or vegetables. Dietary iron was lower in cases (p = 0.04), and cases were more likely to consume below recommended guidelines of iron (77.2% of cases vs 62.9% of controls, p < 0.001). In multivariable analysis, iron consumption below recommended guidelines was associated with MS (odds ratio = 1.80, p < 0.01). Conclusion: Pediatric MS cases may be less likely to consume sufficient iron compared to controls, and this warrants broader study to characterize a temporal relationship. No other significant difference in intake of most dietary factors was found.

Original languageEnglish (US)
Pages (from-to)1067-1076
Number of pages10
JournalMultiple Sclerosis Journal
Volume24
Issue number8
DOIs
StatePublished - Jul 1 2018

Fingerprint

Multiple Sclerosis
Case-Control Studies
Pediatrics
Iron
Guidelines
Dietary Iron
Age of Onset
Vegetables
Fruit
Logistic Models
Fats
Odds Ratio
Regression Analysis
Carbohydrates
Magnetic Resonance Imaging
Diet
Food
Proteins

Keywords

  • all pediatric
  • Case control studies
  • multiple sclerosis
  • neurology
  • nutritional
  • risk factors in epidemiology

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

Cite this

Dietary factors and pediatric multiple sclerosis : A case-control study. / for the US Network of Pediatric Multiple Sclerosis Centers.

In: Multiple Sclerosis Journal, Vol. 24, No. 8, 01.07.2018, p. 1067-1076.

Research output: Contribution to journalArticle

for the US Network of Pediatric Multiple Sclerosis Centers 2018, 'Dietary factors and pediatric multiple sclerosis: A case-control study', Multiple Sclerosis Journal, vol. 24, no. 8, pp. 1067-1076. https://doi.org/10.1177/1352458517713343
for the US Network of Pediatric Multiple Sclerosis Centers. Dietary factors and pediatric multiple sclerosis: A case-control study. Multiple Sclerosis Journal. 2018 Jul 1;24(8):1067-1076. https://doi.org/10.1177/1352458517713343
for the US Network of Pediatric Multiple Sclerosis Centers. / Dietary factors and pediatric multiple sclerosis : A case-control study. In: Multiple Sclerosis Journal. 2018 ; Vol. 24, No. 8. pp. 1067-1076.
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title = "Dietary factors and pediatric multiple sclerosis: A case-control study",
abstract = "Background: The role of diet in multiple sclerosis (MS) is largely uncharacterized, particularly as it pertains to pediatric-onset disease. Objective: To determine the association between dietary factors and MS in children. Methods: Pediatric MS patients and controls were recruited from 16 US centers (MS or clinically isolated syndrome onset before age 18, <4 years from symptom onset and at least 2 silent lesions on magnetic resonance imaging). The validated Block Kids Food Screener questionnaire was administered 2011–2016. Chi-squared test compared categorical variables, Kruskal–Wallis test compared continuous variables, and multivariable logistic regression analysis was performed. Results: In total, 312 cases and 456 controls were included (mean ages 15.1 and 14.4 years). In unadjusted analyses, there was no difference in intake of fats, proteins, carbohydrates, sugars, fruits, or vegetables. Dietary iron was lower in cases (p = 0.04), and cases were more likely to consume below recommended guidelines of iron (77.2{\%} of cases vs 62.9{\%} of controls, p < 0.001). In multivariable analysis, iron consumption below recommended guidelines was associated with MS (odds ratio = 1.80, p < 0.01). Conclusion: Pediatric MS cases may be less likely to consume sufficient iron compared to controls, and this warrants broader study to characterize a temporal relationship. No other significant difference in intake of most dietary factors was found.",
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author = "{for the US Network of Pediatric Multiple Sclerosis Centers} and Julia Pakpoor and Brandon Seminatore and Graves, {Jennifer S.} and Teri Schreiner and Waldman, {Amy T.} and Lotze, {Timothy E.} and Anita Belman and Greenberg, {Benjamin M.} and Bianca Weinstock-Guttman and Gregory Aaen and Tillema, {Jan Mendelt} and McDonald, {Jamie C.} and Janace Hart and Ness, {Jayne M.} and Yolanda Harris and Jennifer Rubin and Meghan Candee and Lauren Krupp and Mark Gorman and Leslie Benson and Moses Rodriguez and Tanuja Chitnis and Soe Mar and Ilana Kahn and John Rose and Carmichael, {Suzan L.} and Shelly Roalstad and Michael Waltz and Casper, {T. Charles} and Emmanuelle Waubant",
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AU - Pakpoor, Julia

AU - Seminatore, Brandon

AU - Graves, Jennifer S.

AU - Schreiner, Teri

AU - Waldman, Amy T.

AU - Lotze, Timothy E.

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AU - Greenberg, Benjamin M.

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AU - Harris, Yolanda

AU - Rubin, Jennifer

AU - Candee, Meghan

AU - Krupp, Lauren

AU - Gorman, Mark

AU - Benson, Leslie

AU - Rodriguez, Moses

AU - Chitnis, Tanuja

AU - Mar, Soe

AU - Kahn, Ilana

AU - Rose, John

AU - Carmichael, Suzan L.

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N2 - Background: The role of diet in multiple sclerosis (MS) is largely uncharacterized, particularly as it pertains to pediatric-onset disease. Objective: To determine the association between dietary factors and MS in children. Methods: Pediatric MS patients and controls were recruited from 16 US centers (MS or clinically isolated syndrome onset before age 18, <4 years from symptom onset and at least 2 silent lesions on magnetic resonance imaging). The validated Block Kids Food Screener questionnaire was administered 2011–2016. Chi-squared test compared categorical variables, Kruskal–Wallis test compared continuous variables, and multivariable logistic regression analysis was performed. Results: In total, 312 cases and 456 controls were included (mean ages 15.1 and 14.4 years). In unadjusted analyses, there was no difference in intake of fats, proteins, carbohydrates, sugars, fruits, or vegetables. Dietary iron was lower in cases (p = 0.04), and cases were more likely to consume below recommended guidelines of iron (77.2% of cases vs 62.9% of controls, p < 0.001). In multivariable analysis, iron consumption below recommended guidelines was associated with MS (odds ratio = 1.80, p < 0.01). Conclusion: Pediatric MS cases may be less likely to consume sufficient iron compared to controls, and this warrants broader study to characterize a temporal relationship. No other significant difference in intake of most dietary factors was found.

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