Dietary influences on serum lipids and lipoproteins

Scott M Grundy, M. A. Denke

Research output: Contribution to journalArticle

890 Citations (Scopus)

Abstract

Substantial data are available to indicate that the diet influences serum levels of cholesterol and lipoproteins. These data are derived from studies in laboratory animals, from epidemiologic studies, and from human investigations. Most research has focused on effects of diet on serum total cholesterol concentrations. In recent years, however, attention has shifted to individual lipoproteins, i.e., low density lipoproteins (LDL), high density lipoproteins (HDL), and very low density lipoproteins (VLDL). Three nutritional factors have been identified that raise serum LDL levels; these are saturated fatty acids, cholesterol itself, and excess caloric intake leading to obesity. The major cholesterol-raising saturated fatty acid in the diet is palmitic acid. Several nutrients can be substituted for saturated fatty acids to produce a reduction in LDL-cholesterol levels. These are polyunsaturated fatty acids, monounsaturated fatty acids, carbohydrates, and even one saturated fatty acid, stearic acid. The latter appears to be converted rapidly into a mono-unsaturated fatty acid in the body. Any of these nutrients can be used for replacement of cholesterol-raising saturated fatty acids in the diet. However, their relative effects on other metabolic processes remain to be determined fully. At present it appears that carbohydrates and monounsaturated fatty acids represent the preferred replacements for saturated fatty acids, although modest increases in polyunsaturated fatty acids and stearic acid, at the expense of cholesterol-raising saturates, probably are safe and may provide for greater variety in the diet.

Original languageEnglish (US)
Pages (from-to)1149-1172
Number of pages24
JournalJournal of Lipid Research
Volume31
Issue number7
StatePublished - 1990

Fingerprint

Lipoproteins
Nutrition
Fatty Acids
Lipids
Cholesterol
Diet
Serum
Unsaturated Fatty Acids
Monounsaturated Fatty Acids
LDL Lipoproteins
Nutrients
Monounsaturated fatty acids
Carbohydrates
Food
Palmitic Acid
VLDL Lipoproteins
Laboratory Animals
HDL Lipoproteins
Energy Intake
LDL Cholesterol

Keywords

  • Cholesterol
  • HDL
  • LDL
  • Monounsaturated fatty acids
  • obesity
  • Poly-unsaturated fatty acids
  • Saturated fatty acids
  • VLDL

ASJC Scopus subject areas

  • Endocrinology

Cite this

Dietary influences on serum lipids and lipoproteins. / Grundy, Scott M; Denke, M. A.

In: Journal of Lipid Research, Vol. 31, No. 7, 1990, p. 1149-1172.

Research output: Contribution to journalArticle

Grundy, Scott M ; Denke, M. A. / Dietary influences on serum lipids and lipoproteins. In: Journal of Lipid Research. 1990 ; Vol. 31, No. 7. pp. 1149-1172.
@article{2fede8e472ea4650bac23693aea5ca07,
title = "Dietary influences on serum lipids and lipoproteins",
abstract = "Substantial data are available to indicate that the diet influences serum levels of cholesterol and lipoproteins. These data are derived from studies in laboratory animals, from epidemiologic studies, and from human investigations. Most research has focused on effects of diet on serum total cholesterol concentrations. In recent years, however, attention has shifted to individual lipoproteins, i.e., low density lipoproteins (LDL), high density lipoproteins (HDL), and very low density lipoproteins (VLDL). Three nutritional factors have been identified that raise serum LDL levels; these are saturated fatty acids, cholesterol itself, and excess caloric intake leading to obesity. The major cholesterol-raising saturated fatty acid in the diet is palmitic acid. Several nutrients can be substituted for saturated fatty acids to produce a reduction in LDL-cholesterol levels. These are polyunsaturated fatty acids, monounsaturated fatty acids, carbohydrates, and even one saturated fatty acid, stearic acid. The latter appears to be converted rapidly into a mono-unsaturated fatty acid in the body. Any of these nutrients can be used for replacement of cholesterol-raising saturated fatty acids in the diet. However, their relative effects on other metabolic processes remain to be determined fully. At present it appears that carbohydrates and monounsaturated fatty acids represent the preferred replacements for saturated fatty acids, although modest increases in polyunsaturated fatty acids and stearic acid, at the expense of cholesterol-raising saturates, probably are safe and may provide for greater variety in the diet.",
keywords = "Cholesterol, HDL, LDL, Monounsaturated fatty acids, obesity, Poly-unsaturated fatty acids, Saturated fatty acids, VLDL",
author = "Grundy, {Scott M} and Denke, {M. A.}",
year = "1990",
language = "English (US)",
volume = "31",
pages = "1149--1172",
journal = "Journal of Lipid Research",
issn = "0022-2275",
publisher = "American Society for Biochemistry and Molecular Biology Inc.",
number = "7",

}

TY - JOUR

T1 - Dietary influences on serum lipids and lipoproteins

AU - Grundy, Scott M

AU - Denke, M. A.

PY - 1990

Y1 - 1990

N2 - Substantial data are available to indicate that the diet influences serum levels of cholesterol and lipoproteins. These data are derived from studies in laboratory animals, from epidemiologic studies, and from human investigations. Most research has focused on effects of diet on serum total cholesterol concentrations. In recent years, however, attention has shifted to individual lipoproteins, i.e., low density lipoproteins (LDL), high density lipoproteins (HDL), and very low density lipoproteins (VLDL). Three nutritional factors have been identified that raise serum LDL levels; these are saturated fatty acids, cholesterol itself, and excess caloric intake leading to obesity. The major cholesterol-raising saturated fatty acid in the diet is palmitic acid. Several nutrients can be substituted for saturated fatty acids to produce a reduction in LDL-cholesterol levels. These are polyunsaturated fatty acids, monounsaturated fatty acids, carbohydrates, and even one saturated fatty acid, stearic acid. The latter appears to be converted rapidly into a mono-unsaturated fatty acid in the body. Any of these nutrients can be used for replacement of cholesterol-raising saturated fatty acids in the diet. However, their relative effects on other metabolic processes remain to be determined fully. At present it appears that carbohydrates and monounsaturated fatty acids represent the preferred replacements for saturated fatty acids, although modest increases in polyunsaturated fatty acids and stearic acid, at the expense of cholesterol-raising saturates, probably are safe and may provide for greater variety in the diet.

AB - Substantial data are available to indicate that the diet influences serum levels of cholesterol and lipoproteins. These data are derived from studies in laboratory animals, from epidemiologic studies, and from human investigations. Most research has focused on effects of diet on serum total cholesterol concentrations. In recent years, however, attention has shifted to individual lipoproteins, i.e., low density lipoproteins (LDL), high density lipoproteins (HDL), and very low density lipoproteins (VLDL). Three nutritional factors have been identified that raise serum LDL levels; these are saturated fatty acids, cholesterol itself, and excess caloric intake leading to obesity. The major cholesterol-raising saturated fatty acid in the diet is palmitic acid. Several nutrients can be substituted for saturated fatty acids to produce a reduction in LDL-cholesterol levels. These are polyunsaturated fatty acids, monounsaturated fatty acids, carbohydrates, and even one saturated fatty acid, stearic acid. The latter appears to be converted rapidly into a mono-unsaturated fatty acid in the body. Any of these nutrients can be used for replacement of cholesterol-raising saturated fatty acids in the diet. However, their relative effects on other metabolic processes remain to be determined fully. At present it appears that carbohydrates and monounsaturated fatty acids represent the preferred replacements for saturated fatty acids, although modest increases in polyunsaturated fatty acids and stearic acid, at the expense of cholesterol-raising saturates, probably are safe and may provide for greater variety in the diet.

KW - Cholesterol

KW - HDL

KW - LDL

KW - Monounsaturated fatty acids

KW - obesity

KW - Poly-unsaturated fatty acids

KW - Saturated fatty acids

KW - VLDL

UR - http://www.scopus.com/inward/record.url?scp=0025280487&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0025280487&partnerID=8YFLogxK

M3 - Article

C2 - 2205699

AN - SCOPUS:0025280487

VL - 31

SP - 1149

EP - 1172

JO - Journal of Lipid Research

JF - Journal of Lipid Research

SN - 0022-2275

IS - 7

ER -