Dietary lignan intake and androgen receptor expression in breast tumors

AnnaLynn L M Williams, Matthew Bonner, Heather M. Ochs-Balcom, Helena Hwang, Carl Morrison, Susan E. McCann

Research output: Contribution to journalArticle

Abstract

Purpose: Lignans, a class of phytoestrogen commonly found in the Western diet, have been linked to decreased breast cancer risks in epidemiologic studies. Similar to estrogen receptors, the androgen receptor (AR), a prognostic factor in breast tumors, may be affected by lignans. However, few studies have investigated this link in the context of breast cancer etiology. We evaluated the relationship between dietary lignan intake and AR expression in incident breast tumors. Methods: Tumor tissue, epidemiological, and clinical data were collected from 216 women with incident, primary, histologically confirmed breast cancer enrolled in the Roswell Park Cancer Institute (RPCI) Data Bank and BioRepository (DBBR). On average, three tumor cores from each participant were assembled into a tissue micro array. After immunohistochemical staining, a trained RPCI pathologist determined AR status of each core. Lignan intake was calculated from a food frequency questionnaire collected upon enrollment into the DBBR. Results: We observed a weak positive association between dietary lignans and AR expression [β (SE) 27.6 (17.0), p 0.10], and there was no significant difference in lignan intake across categories of AR expression (p = 0.09, R<sup>2</sup> = 0.35). Conclusion: Our results do not support a clear relationship between dietary lignan intake and AR expression. This investigation is the first, to our knowledge, to examine dietary lignan intake and AR expression in breast tumors. Further research is needed within a larger, more representative sample to determine whether lignan intake is truly associated with AR expression.

Original languageEnglish (US)
Pages (from-to)311-317
Number of pages7
JournalCancer Causes and Control
Volume26
Issue number2
DOIs
StatePublished - 2015

Fingerprint

Lignans
Androgen Receptors
Breast Neoplasms
Neoplasms
Databases
Phytoestrogens
Estrogen Receptors
Epidemiologic Studies
Staining and Labeling
Food

Keywords

  • Androgen receptor
  • Breast cancer
  • Dietary lignans
  • Tissue microarray

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Williams, A. L. M., Bonner, M., Ochs-Balcom, H. M., Hwang, H., Morrison, C., & McCann, S. E. (2015). Dietary lignan intake and androgen receptor expression in breast tumors. Cancer Causes and Control, 26(2), 311-317. https://doi.org/10.1007/s10552-014-0504-1

Dietary lignan intake and androgen receptor expression in breast tumors. / Williams, AnnaLynn L M; Bonner, Matthew; Ochs-Balcom, Heather M.; Hwang, Helena; Morrison, Carl; McCann, Susan E.

In: Cancer Causes and Control, Vol. 26, No. 2, 2015, p. 311-317.

Research output: Contribution to journalArticle

Williams, ALM, Bonner, M, Ochs-Balcom, HM, Hwang, H, Morrison, C & McCann, SE 2015, 'Dietary lignan intake and androgen receptor expression in breast tumors', Cancer Causes and Control, vol. 26, no. 2, pp. 311-317. https://doi.org/10.1007/s10552-014-0504-1
Williams, AnnaLynn L M ; Bonner, Matthew ; Ochs-Balcom, Heather M. ; Hwang, Helena ; Morrison, Carl ; McCann, Susan E. / Dietary lignan intake and androgen receptor expression in breast tumors. In: Cancer Causes and Control. 2015 ; Vol. 26, No. 2. pp. 311-317.
@article{7323104f5f0a481bb3a1e7580be1aae3,
title = "Dietary lignan intake and androgen receptor expression in breast tumors",
abstract = "Purpose: Lignans, a class of phytoestrogen commonly found in the Western diet, have been linked to decreased breast cancer risks in epidemiologic studies. Similar to estrogen receptors, the androgen receptor (AR), a prognostic factor in breast tumors, may be affected by lignans. However, few studies have investigated this link in the context of breast cancer etiology. We evaluated the relationship between dietary lignan intake and AR expression in incident breast tumors. Methods: Tumor tissue, epidemiological, and clinical data were collected from 216 women with incident, primary, histologically confirmed breast cancer enrolled in the Roswell Park Cancer Institute (RPCI) Data Bank and BioRepository (DBBR). On average, three tumor cores from each participant were assembled into a tissue micro array. After immunohistochemical staining, a trained RPCI pathologist determined AR status of each core. Lignan intake was calculated from a food frequency questionnaire collected upon enrollment into the DBBR. Results: We observed a weak positive association between dietary lignans and AR expression [β (SE) 27.6 (17.0), p 0.10], and there was no significant difference in lignan intake across categories of AR expression (p = 0.09, R2 = 0.35). Conclusion: Our results do not support a clear relationship between dietary lignan intake and AR expression. This investigation is the first, to our knowledge, to examine dietary lignan intake and AR expression in breast tumors. Further research is needed within a larger, more representative sample to determine whether lignan intake is truly associated with AR expression.",
keywords = "Androgen receptor, Breast cancer, Dietary lignans, Tissue microarray",
author = "Williams, {AnnaLynn L M} and Matthew Bonner and Ochs-Balcom, {Heather M.} and Helena Hwang and Carl Morrison and McCann, {Susan E.}",
year = "2015",
doi = "10.1007/s10552-014-0504-1",
language = "English (US)",
volume = "26",
pages = "311--317",
journal = "Cancer Causes and Control",
issn = "0957-5243",
publisher = "Springer Netherlands",
number = "2",

}

TY - JOUR

T1 - Dietary lignan intake and androgen receptor expression in breast tumors

AU - Williams, AnnaLynn L M

AU - Bonner, Matthew

AU - Ochs-Balcom, Heather M.

AU - Hwang, Helena

AU - Morrison, Carl

AU - McCann, Susan E.

PY - 2015

Y1 - 2015

N2 - Purpose: Lignans, a class of phytoestrogen commonly found in the Western diet, have been linked to decreased breast cancer risks in epidemiologic studies. Similar to estrogen receptors, the androgen receptor (AR), a prognostic factor in breast tumors, may be affected by lignans. However, few studies have investigated this link in the context of breast cancer etiology. We evaluated the relationship between dietary lignan intake and AR expression in incident breast tumors. Methods: Tumor tissue, epidemiological, and clinical data were collected from 216 women with incident, primary, histologically confirmed breast cancer enrolled in the Roswell Park Cancer Institute (RPCI) Data Bank and BioRepository (DBBR). On average, three tumor cores from each participant were assembled into a tissue micro array. After immunohistochemical staining, a trained RPCI pathologist determined AR status of each core. Lignan intake was calculated from a food frequency questionnaire collected upon enrollment into the DBBR. Results: We observed a weak positive association between dietary lignans and AR expression [β (SE) 27.6 (17.0), p 0.10], and there was no significant difference in lignan intake across categories of AR expression (p = 0.09, R2 = 0.35). Conclusion: Our results do not support a clear relationship between dietary lignan intake and AR expression. This investigation is the first, to our knowledge, to examine dietary lignan intake and AR expression in breast tumors. Further research is needed within a larger, more representative sample to determine whether lignan intake is truly associated with AR expression.

AB - Purpose: Lignans, a class of phytoestrogen commonly found in the Western diet, have been linked to decreased breast cancer risks in epidemiologic studies. Similar to estrogen receptors, the androgen receptor (AR), a prognostic factor in breast tumors, may be affected by lignans. However, few studies have investigated this link in the context of breast cancer etiology. We evaluated the relationship between dietary lignan intake and AR expression in incident breast tumors. Methods: Tumor tissue, epidemiological, and clinical data were collected from 216 women with incident, primary, histologically confirmed breast cancer enrolled in the Roswell Park Cancer Institute (RPCI) Data Bank and BioRepository (DBBR). On average, three tumor cores from each participant were assembled into a tissue micro array. After immunohistochemical staining, a trained RPCI pathologist determined AR status of each core. Lignan intake was calculated from a food frequency questionnaire collected upon enrollment into the DBBR. Results: We observed a weak positive association between dietary lignans and AR expression [β (SE) 27.6 (17.0), p 0.10], and there was no significant difference in lignan intake across categories of AR expression (p = 0.09, R2 = 0.35). Conclusion: Our results do not support a clear relationship between dietary lignan intake and AR expression. This investigation is the first, to our knowledge, to examine dietary lignan intake and AR expression in breast tumors. Further research is needed within a larger, more representative sample to determine whether lignan intake is truly associated with AR expression.

KW - Androgen receptor

KW - Breast cancer

KW - Dietary lignans

KW - Tissue microarray

UR - http://www.scopus.com/inward/record.url?scp=84925503159&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84925503159&partnerID=8YFLogxK

U2 - 10.1007/s10552-014-0504-1

DO - 10.1007/s10552-014-0504-1

M3 - Article

C2 - 25471060

AN - SCOPUS:84925503159

VL - 26

SP - 311

EP - 317

JO - Cancer Causes and Control

JF - Cancer Causes and Control

SN - 0957-5243

IS - 2

ER -