Dietary salt loading increases nitric oxide synthesis in transgenic mice overexpressing sodium-proton exchanger

Jun Ichi Kiraku, Tetsuya Nakamura, Takao Sugiyama, Naoyuki Takahashi, Makoto Kuro-o, Jun Fujii, Ryozo Nagai

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

We studied the role of nitric oxide (NO) synthesis in amelioration of blood pressure elevation during dietary salt loading in transgenic mice overexpressing sodium proton exchanger. Systolic blood pressure rose after starting salt loading only in the high-salt group of transgenic mice. However, this elevation of blood pressure was not continued. Urinary excretion of inorganic nitrite and nitrate in the high-salt group of transgenic mice was significantly higher than in the high-salt group of control mice. These results suggest that increased NO synthesis in response to salt loading is one of the anti-hypertensive mechanisms in transgenic mice overexpressing sodium proton exchanger.

Original languageEnglish (US)
Pages (from-to)181-183
Number of pages3
JournalJapanese Journal of Pharmacology
Volume80
Issue number2
DOIs
StatePublished - 1999

Keywords

  • Hypertension
  • Nitric oxide
  • Sodium-proton exchanger

ASJC Scopus subject areas

  • Pharmacology

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    Kiraku, J. I., Nakamura, T., Sugiyama, T., Takahashi, N., Kuro-o, M., Fujii, J., & Nagai, R. (1999). Dietary salt loading increases nitric oxide synthesis in transgenic mice overexpressing sodium-proton exchanger. Japanese Journal of Pharmacology, 80(2), 181-183. https://doi.org/10.1254/jjp.80.181