Differences in clinical and convalescent phase antibodies of rhesus monkeys infected with monkey pox, Tanapox, and Yaba poxviruses

R. D. Hall, R. G. Olsen, S. P. Pakes, D. S. Yohn

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Complement fixing and complement fixing inhibiting (CFI) antibodies were demonstrated in the clinical and convalescent stages, respectively, of rhesus monkeys infected with either monkey poxvirus, Tanapoxvirus, or Yaba poxvirus. Specificity of the CFI antibody was confirmed by its failure to cross react with heterologous poxvirus antigens and by experiments demonstrating the CFI test as being antigen dependent. Serum containing CFI antibody neutralized homologous poxvirus but failed to agglutinate antigen coated, tanned red blood cells. The application of CFI test as a seroepidemiologic tool for studies of poxvirus infection of man and simian monkeys and the biologic role of CFI antibody in pathogenesis were discussed.

Original languageEnglish (US)
Pages (from-to)539-546
Number of pages8
JournalInfection and Immunity
Volume7
Issue number4
StatePublished - 1973

Fingerprint

Monkeypox
Poxviridae
Macaca mulatta
Antibodies
Haplorhini
Poxviridae Infections
Heterophile Antigens
Antigens
Seroepidemiologic Studies
Erythrocytes
Serum

ASJC Scopus subject areas

  • Immunology

Cite this

Differences in clinical and convalescent phase antibodies of rhesus monkeys infected with monkey pox, Tanapox, and Yaba poxviruses. / Hall, R. D.; Olsen, R. G.; Pakes, S. P.; Yohn, D. S.

In: Infection and Immunity, Vol. 7, No. 4, 1973, p. 539-546.

Research output: Contribution to journalArticle

@article{6700afad78164276a787451a2e0f85cf,
title = "Differences in clinical and convalescent phase antibodies of rhesus monkeys infected with monkey pox, Tanapox, and Yaba poxviruses",
abstract = "Complement fixing and complement fixing inhibiting (CFI) antibodies were demonstrated in the clinical and convalescent stages, respectively, of rhesus monkeys infected with either monkey poxvirus, Tanapoxvirus, or Yaba poxvirus. Specificity of the CFI antibody was confirmed by its failure to cross react with heterologous poxvirus antigens and by experiments demonstrating the CFI test as being antigen dependent. Serum containing CFI antibody neutralized homologous poxvirus but failed to agglutinate antigen coated, tanned red blood cells. The application of CFI test as a seroepidemiologic tool for studies of poxvirus infection of man and simian monkeys and the biologic role of CFI antibody in pathogenesis were discussed.",
author = "Hall, {R. D.} and Olsen, {R. G.} and Pakes, {S. P.} and Yohn, {D. S.}",
year = "1973",
language = "English (US)",
volume = "7",
pages = "539--546",
journal = "Infection and Immunity",
issn = "0019-9567",
publisher = "American Society for Microbiology",
number = "4",

}

TY - JOUR

T1 - Differences in clinical and convalescent phase antibodies of rhesus monkeys infected with monkey pox, Tanapox, and Yaba poxviruses

AU - Hall, R. D.

AU - Olsen, R. G.

AU - Pakes, S. P.

AU - Yohn, D. S.

PY - 1973

Y1 - 1973

N2 - Complement fixing and complement fixing inhibiting (CFI) antibodies were demonstrated in the clinical and convalescent stages, respectively, of rhesus monkeys infected with either monkey poxvirus, Tanapoxvirus, or Yaba poxvirus. Specificity of the CFI antibody was confirmed by its failure to cross react with heterologous poxvirus antigens and by experiments demonstrating the CFI test as being antigen dependent. Serum containing CFI antibody neutralized homologous poxvirus but failed to agglutinate antigen coated, tanned red blood cells. The application of CFI test as a seroepidemiologic tool for studies of poxvirus infection of man and simian monkeys and the biologic role of CFI antibody in pathogenesis were discussed.

AB - Complement fixing and complement fixing inhibiting (CFI) antibodies were demonstrated in the clinical and convalescent stages, respectively, of rhesus monkeys infected with either monkey poxvirus, Tanapoxvirus, or Yaba poxvirus. Specificity of the CFI antibody was confirmed by its failure to cross react with heterologous poxvirus antigens and by experiments demonstrating the CFI test as being antigen dependent. Serum containing CFI antibody neutralized homologous poxvirus but failed to agglutinate antigen coated, tanned red blood cells. The application of CFI test as a seroepidemiologic tool for studies of poxvirus infection of man and simian monkeys and the biologic role of CFI antibody in pathogenesis were discussed.

UR - http://www.scopus.com/inward/record.url?scp=0015839633&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0015839633&partnerID=8YFLogxK

M3 - Article

VL - 7

SP - 539

EP - 546

JO - Infection and Immunity

JF - Infection and Immunity

SN - 0019-9567

IS - 4

ER -