Different neural circuits subserve reading before and after therapy for acquired dyslexia

Steven L. Small, Diane Kendall Flores, Douglas C. Noll

Research output: Contribution to journalArticle

85 Citations (Scopus)

Abstract

Rehabilitative measures for stroke are not generally based on basic neurobiological principles, despite evidence from animal models that certain anatomical and pharmacological changes correlate with recovery. In this report, we use functional magnetic resonance imaging (fMRI) to study in vivo human brain reorganization in a right handed patient with an acquired reading disorder from stroke. With phonological dyslexia, her whole-word (lexical) reading approach included inability to read nonwords and poor reading of function words. Following therapy, she was able to read nonwords and function words, and preferred a decompositional (sublexical) strategy in general. fMRI was performed during a reading task before and after treatment. Prior to therapy, her main focus of brain activation was in the left angular gyms (area 39). After therapy, it was instead in the left lingual gyrus (area 18). This result suggests first that it is possible to alter brain physiology with therapy for acquired language disorders, and second, that two reading strategies commonly used in normal reading use distinct neural circuits, possibly reconciling several conflicting neuroimaging studies of reading.

Original languageEnglish (US)
Pages (from-to)298-308
Number of pages11
JournalBrain and language
Volume62
Issue number2
DOIs
StatePublished - Apr 1998
Externally publishedYes

Fingerprint

Acquired Dyslexia
dyslexia
Reading
Dyslexia
brain
stroke
Brain
Therapeutics
Stroke
Magnetic Resonance Imaging
Language Disorders
Occipital Lobe
patient's rights
Patient Rights
Neuroimaging
physiology
Therapy
reorganization
activation
Animal Models

ASJC Scopus subject areas

  • Experimental and Cognitive Psychology
  • Language and Linguistics
  • Linguistics and Language
  • Cognitive Neuroscience
  • Speech and Hearing

Cite this

Different neural circuits subserve reading before and after therapy for acquired dyslexia. / Small, Steven L.; Flores, Diane Kendall; Noll, Douglas C.

In: Brain and language, Vol. 62, No. 2, 04.1998, p. 298-308.

Research output: Contribution to journalArticle

Small, Steven L. ; Flores, Diane Kendall ; Noll, Douglas C. / Different neural circuits subserve reading before and after therapy for acquired dyslexia. In: Brain and language. 1998 ; Vol. 62, No. 2. pp. 298-308.
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