Different originating cells underlie intertumoral heterogeneity in lung neuroendocrine tumors

Research output: Contribution to journalArticle

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Abstract

Studies in genetically engineered mouse models of neuroendocrine lung cancer suggest that differences in cells of origin underlie subtype variations in this class of cancers. These findings highlight the concept that the same driver mutations introduced into different cells of origin lead to tumors with the same histology but dramatically different metastatic programs and potentially different therapeutic responses.

Original languageEnglish (US)
Pages (from-to)1216-1218
Number of pages3
JournalCancer Discovery
Volume8
Issue number10
DOIs
Publication statusPublished - Oct 1 2018

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ASJC Scopus subject areas

  • Oncology

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