Different originating cells underlie intertumoral heterogeneity in lung neuroendocrine tumors

Karine Pozo; Demetra P. Kelenis; John D. Minna; Jane E. Johnson

doi:10.1158/2159-8290.CD-18-0979

Different originating cells underlie intertumoral heterogeneity in lung neuroendocrine tumors

Karine Pozo, Demetra P. Kelenis, John D. Minna, Jane E. Johnson

Research output: Contribution to journal › Article

1 Scopus citations

Abstract

Studies in genetically engineered mouse models of neuroendocrine lung cancer suggest that differences in cells of origin underlie subtype variations in this class of cancers. These findings highlight the concept that the same driver mutations introduced into different cells of origin lead to tumors with the same histology but dramatically different metastatic programs and potentially different therapeutic responses.

Original language	English (US)
Pages (from-to)	1216-1218
Number of pages	3
Journal	Cancer discovery
Volume	8
Issue number	10
DOIs	https://doi.org/10.1158/2159-8290.CD-18-0979
State	Published - Oct 2018

ASJC Scopus subject areas

Oncology

Access to Document

10.1158/2159-8290.CD-18-0979

Fingerprint Dive into the research topics of 'Different originating cells underlie intertumoral heterogeneity in lung neuroendocrine tumors'. Together they form a unique fingerprint.

Cite this

Pozo, K., Kelenis, D. P., Minna, J. D., & Johnson, J. E. (2018). Different originating cells underlie intertumoral heterogeneity in lung neuroendocrine tumors. Cancer discovery, 8(10), 1216-1218. https://doi.org/10.1158/2159-8290.CD-18-0979

@article{0e721c401f224ccb96f3a246e22f2eef,

title = "Different originating cells underlie intertumoral heterogeneity in lung neuroendocrine tumors",

abstract = "Studies in genetically engineered mouse models of neuroendocrine lung cancer suggest that differences in cells of origin underlie subtype variations in this class of cancers. These findings highlight the concept that the same driver mutations introduced into different cells of origin lead to tumors with the same histology but dramatically different metastatic programs and potentially different therapeutic responses.",

author = "Karine Pozo and Kelenis, {Demetra P.} and Minna, {John D.} and Johnson, {Jane E.}",

year = "2018",

month = oct,

doi = "10.1158/2159-8290.CD-18-0979",

language = "English (US)",

volume = "8",

pages = "1216--1218",

journal = "Cancer Discovery",

issn = "2159-8274",

publisher = "American Association for Cancer Research Inc.",

number = "10",

}

TY - JOUR

T1 - Different originating cells underlie intertumoral heterogeneity in lung neuroendocrine tumors

AU - Pozo, Karine

AU - Kelenis, Demetra P.

AU - Minna, John D.

AU - Johnson, Jane E.

PY - 2018/10

Y1 - 2018/10

N2 - Studies in genetically engineered mouse models of neuroendocrine lung cancer suggest that differences in cells of origin underlie subtype variations in this class of cancers. These findings highlight the concept that the same driver mutations introduced into different cells of origin lead to tumors with the same histology but dramatically different metastatic programs and potentially different therapeutic responses.

AB - Studies in genetically engineered mouse models of neuroendocrine lung cancer suggest that differences in cells of origin underlie subtype variations in this class of cancers. These findings highlight the concept that the same driver mutations introduced into different cells of origin lead to tumors with the same histology but dramatically different metastatic programs and potentially different therapeutic responses.

UR - http://www.scopus.com/inward/record.url?scp=85054368674&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85054368674&partnerID=8YFLogxK

U2 - 10.1158/2159-8290.CD-18-0979

DO - 10.1158/2159-8290.CD-18-0979

M3 - Article

C2 - 30279195

AN - SCOPUS:85054368674

VL - 8

SP - 1216

EP - 1218

JO - Cancer Discovery

JF - Cancer Discovery

SN - 2159-8274

IS - 10

ER -