Differential effects from parapyramidal region and rostral ventrolateral medulla mediated by substance P

Kenneth Swiatkowski, Lynn M. Dellamano, John Vissing, Kenneth J. Rybicki, Gerald P. Kozlowski, Gary A. Iwamoto

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Rostral ventrolateral medulla (rVLM) and parapyramidal region (PPr) serve as important medullary control sites for sympathoexcitation, rVLM and PPr have direct projections to the intermediolateral cell column (IML) that are thought to be important in maintaining mean arterial blood pressure (MAP). Substance P (SP) is found in PPr neurons and in and near the subretrofacial area of the rVLM. At least some of these cells project to the IML. We investigated the involvement of SP at the IML in mediating rVLM- and PPr-evoked pressor responses in the chloraloseanesthetized cat. Pressor responses to electrical and chemical PPr and rVLM stimulation were altered after intrathecal injection, at the level of the T1-T3 spinal cord, of either SP antagonist [D-Pro2, D-Phe7, D-Trp9]-SP, SP antagonist CP 96,345, or SP antiserum. Although MAP and heart rate responses to PPr stimulation were attenuated by intrathecal SP antagonists or antiserum, MAP responses to rVLM stimulation were augmented. Previous studies have revealed differences in transmitters associated with these two areas, even though the general response of both areas is sympathoexcitatory. The present study implies that the identical substance may increase or decrease the MAP response depending on the pathway activated.

Original languageEnglish (US)
JournalAmerican Journal of Physiology - Regulatory Integrative and Comparative Physiology
Volume277
Issue number4 46-4
StatePublished - Oct 1999

Fingerprint

Substance P
Arterial Pressure
Immune Sera
Spinal Injections
Spinal Cord
Cats
Heart Rate
Neurons

Keywords

  • Brain stem
  • Cats
  • CP 96,345
  • Intermediolateral cell column
  • Pressor responses

ASJC Scopus subject areas

  • Physiology
  • Physiology (medical)

Cite this

Differential effects from parapyramidal region and rostral ventrolateral medulla mediated by substance P. / Swiatkowski, Kenneth; Dellamano, Lynn M.; Vissing, John; Rybicki, Kenneth J.; Kozlowski, Gerald P.; Iwamoto, Gary A.

In: American Journal of Physiology - Regulatory Integrative and Comparative Physiology, Vol. 277, No. 4 46-4, 10.1999.

Research output: Contribution to journalArticle

Swiatkowski, Kenneth ; Dellamano, Lynn M. ; Vissing, John ; Rybicki, Kenneth J. ; Kozlowski, Gerald P. ; Iwamoto, Gary A. / Differential effects from parapyramidal region and rostral ventrolateral medulla mediated by substance P. In: American Journal of Physiology - Regulatory Integrative and Comparative Physiology. 1999 ; Vol. 277, No. 4 46-4.
@article{17fc73d3e4e143aa95fdf0f02bcb97b5,
title = "Differential effects from parapyramidal region and rostral ventrolateral medulla mediated by substance P",
abstract = "Rostral ventrolateral medulla (rVLM) and parapyramidal region (PPr) serve as important medullary control sites for sympathoexcitation, rVLM and PPr have direct projections to the intermediolateral cell column (IML) that are thought to be important in maintaining mean arterial blood pressure (MAP). Substance P (SP) is found in PPr neurons and in and near the subretrofacial area of the rVLM. At least some of these cells project to the IML. We investigated the involvement of SP at the IML in mediating rVLM- and PPr-evoked pressor responses in the chloraloseanesthetized cat. Pressor responses to electrical and chemical PPr and rVLM stimulation were altered after intrathecal injection, at the level of the T1-T3 spinal cord, of either SP antagonist [D-Pro2, D-Phe7, D-Trp9]-SP, SP antagonist CP 96,345, or SP antiserum. Although MAP and heart rate responses to PPr stimulation were attenuated by intrathecal SP antagonists or antiserum, MAP responses to rVLM stimulation were augmented. Previous studies have revealed differences in transmitters associated with these two areas, even though the general response of both areas is sympathoexcitatory. The present study implies that the identical substance may increase or decrease the MAP response depending on the pathway activated.",
keywords = "Brain stem, Cats, CP 96,345, Intermediolateral cell column, Pressor responses",
author = "Kenneth Swiatkowski and Dellamano, {Lynn M.} and John Vissing and Rybicki, {Kenneth J.} and Kozlowski, {Gerald P.} and Iwamoto, {Gary A.}",
year = "1999",
month = "10",
language = "English (US)",
volume = "277",
journal = "American Journal of Physiology - Heart and Circulatory Physiology",
issn = "0363-6135",
publisher = "American Physiological Society",
number = "4 46-4",

}

TY - JOUR

T1 - Differential effects from parapyramidal region and rostral ventrolateral medulla mediated by substance P

AU - Swiatkowski, Kenneth

AU - Dellamano, Lynn M.

AU - Vissing, John

AU - Rybicki, Kenneth J.

AU - Kozlowski, Gerald P.

AU - Iwamoto, Gary A.

PY - 1999/10

Y1 - 1999/10

N2 - Rostral ventrolateral medulla (rVLM) and parapyramidal region (PPr) serve as important medullary control sites for sympathoexcitation, rVLM and PPr have direct projections to the intermediolateral cell column (IML) that are thought to be important in maintaining mean arterial blood pressure (MAP). Substance P (SP) is found in PPr neurons and in and near the subretrofacial area of the rVLM. At least some of these cells project to the IML. We investigated the involvement of SP at the IML in mediating rVLM- and PPr-evoked pressor responses in the chloraloseanesthetized cat. Pressor responses to electrical and chemical PPr and rVLM stimulation were altered after intrathecal injection, at the level of the T1-T3 spinal cord, of either SP antagonist [D-Pro2, D-Phe7, D-Trp9]-SP, SP antagonist CP 96,345, or SP antiserum. Although MAP and heart rate responses to PPr stimulation were attenuated by intrathecal SP antagonists or antiserum, MAP responses to rVLM stimulation were augmented. Previous studies have revealed differences in transmitters associated with these two areas, even though the general response of both areas is sympathoexcitatory. The present study implies that the identical substance may increase or decrease the MAP response depending on the pathway activated.

AB - Rostral ventrolateral medulla (rVLM) and parapyramidal region (PPr) serve as important medullary control sites for sympathoexcitation, rVLM and PPr have direct projections to the intermediolateral cell column (IML) that are thought to be important in maintaining mean arterial blood pressure (MAP). Substance P (SP) is found in PPr neurons and in and near the subretrofacial area of the rVLM. At least some of these cells project to the IML. We investigated the involvement of SP at the IML in mediating rVLM- and PPr-evoked pressor responses in the chloraloseanesthetized cat. Pressor responses to electrical and chemical PPr and rVLM stimulation were altered after intrathecal injection, at the level of the T1-T3 spinal cord, of either SP antagonist [D-Pro2, D-Phe7, D-Trp9]-SP, SP antagonist CP 96,345, or SP antiserum. Although MAP and heart rate responses to PPr stimulation were attenuated by intrathecal SP antagonists or antiserum, MAP responses to rVLM stimulation were augmented. Previous studies have revealed differences in transmitters associated with these two areas, even though the general response of both areas is sympathoexcitatory. The present study implies that the identical substance may increase or decrease the MAP response depending on the pathway activated.

KW - Brain stem

KW - Cats

KW - CP 96,345

KW - Intermediolateral cell column

KW - Pressor responses

UR - http://www.scopus.com/inward/record.url?scp=0032743316&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0032743316&partnerID=8YFLogxK

M3 - Article

C2 - 10516253

AN - SCOPUS:0032743316

VL - 277

JO - American Journal of Physiology - Heart and Circulatory Physiology

JF - American Journal of Physiology - Heart and Circulatory Physiology

SN - 0363-6135

IS - 4 46-4

ER -