Differential effects of 5-HT 2A and 5-HT 2C receptor blockade on strategy-switching

Phillip M. Baker, Jennifer L. Thompson, John A. Sweeney, Michael E. Ragozzino

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

Recent experiments indicate that blockade of serotonin (5-HT) 2A and 2C receptors have differential effects on reversal learning. The present experiments investigated the effects of the 5-HT 2A receptor antagonist, ketanserin and 5-HT 2C receptor antagonist, SB242084 on acquisition and strategy-switching in a visual cue-response paradigm. Long-Evans rats were trained in a cross-maze to enter an arm based on color (visual cue version) or a specific turn response (response version). Systemic treatment with ketanserin did not affect initial learning of a visual cue or response discrimination, but ketanserin at 0.5mg/kg significantly enhanced a switch between visual cue and response strategies. Ketanserin facilitated strategy-switching by inhibiting responses to a previously relevant strategy without affecting choices to never-reinforced strategies. Treatment with SB242084 (0.5, 1.0 or 2.0mg/kg) did not affect acquisition of a visual cue or response discrimination. SB242084 treatment also did not affect strategy-switching. The present findings suggest that blockade of 5-HT 2A, but not 5-HT 2C, receptors enhance strategy switching.

Original languageEnglish (US)
Pages (from-to)123-131
Number of pages9
JournalBehavioural Brain Research
Volume219
Issue number1
DOIs
StatePublished - May 16 2011

Fingerprint

Receptor, Serotonin, 5-HT2C
Ketanserin
Cues
Serotonin
Receptor, Serotonin, 5-HT2A
Reversal Learning
Long Evans Rats
Color
Learning
6-chloro-5-methyl-1-((2-(2-methylpyrid-3-yloxy)pyrid-5-yl)carbamoyl)indoline

Keywords

  • Cognitive flexibility
  • Ketanserin
  • Learning
  • Rat
  • Serotonin
  • Strategy-switching

ASJC Scopus subject areas

  • Behavioral Neuroscience

Cite this

Differential effects of 5-HT 2A and 5-HT 2C receptor blockade on strategy-switching. / Baker, Phillip M.; Thompson, Jennifer L.; Sweeney, John A.; Ragozzino, Michael E.

In: Behavioural Brain Research, Vol. 219, No. 1, 16.05.2011, p. 123-131.

Research output: Contribution to journalArticle

Baker, Phillip M. ; Thompson, Jennifer L. ; Sweeney, John A. ; Ragozzino, Michael E. / Differential effects of 5-HT 2A and 5-HT 2C receptor blockade on strategy-switching. In: Behavioural Brain Research. 2011 ; Vol. 219, No. 1. pp. 123-131.
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