Differential expression and activation of a family of murine peroxisome proliferator-activated receptors

S. A. Kliewer, B. M. Forman, B. Blumberg, E. S. Ong, U. Borgmeyer, D. J. Mangelsdorf, K. Umesono, R. M. Evans

Research output: Contribution to journalArticle

1216 Scopus citations

Abstract

To gain insight into the function of peroxisome proliferator-activated receptor (PPAR) isoforms in mammals, we have cloned and characterized two PPARα-related cDNAs (designated PPARγ and -δ, respectively) from mouse. The three PPAR isoforms display widely divergent patterns of expression during embryogenesis and in the adult. Surprisingly, PPARγ and -δ are not activated by pirinixic acid (Wy 14,643), a potent peroxisome proliferator and activator of PPARα. However, PPARγ and -δ are activated by the structurally distinct peroxisome proliferator LY-171883 and linoleic acid, respectively, indicating that each of the isoforms can act as a regulated activator of transcription. These data suggest that tissue-specific responsiveness to peroxisome proliferators, including certain fatty acids, is in part a consequence of differential expression of multiple, pharmacologically distinct PPAR isoforms.

Original languageEnglish (US)
Pages (from-to)7355-7359
Number of pages5
JournalProceedings of the National Academy of Sciences of the United States of America
Volume91
Issue number15
DOIs
StatePublished - Jul 19 1994

Keywords

  • fatty acid
  • nuclear hormone receptors
  • β-oxidation

ASJC Scopus subject areas

  • General

Fingerprint Dive into the research topics of 'Differential expression and activation of a family of murine peroxisome proliferator-activated receptors'. Together they form a unique fingerprint.

  • Cite this