Differential expression and activation of a family of murine peroxisome proliferator-activated receptors

S. A. Kliewer, B. M. Forman, B. Blumberg, E. S. Ong, U. Borgmeyer, D. J. Mangelsdorf, K. Umesono, R. M. Evans

Research output: Contribution to journalArticle

1207 Citations (Scopus)

Abstract

To gain insight into the function of peroxisome proliferator-activated receptor (PPAR) isoforms in mammals, we have cloned and characterized two PPARα-related cDNAs (designated PPARγ and -δ, respectively) from mouse. The three PPAR isoforms display widely divergent patterns of expression during embryogenesis and in the adult. Surprisingly, PPARγ and -δ are not activated by pirinixic acid (Wy 14,643), a potent peroxisome proliferator and activator of PPARα. However, PPARγ and -δ are activated by the structurally distinct peroxisome proliferator LY-171883 and linoleic acid, respectively, indicating that each of the isoforms can act as a regulated activator of transcription. These data suggest that tissue-specific responsiveness to peroxisome proliferators, including certain fatty acids, is in part a consequence of differential expression of multiple, pharmacologically distinct PPAR isoforms.

Original languageEnglish (US)
Pages (from-to)7355-7359
Number of pages5
JournalProceedings of the National Academy of Sciences of the United States of America
Volume91
Issue number15
DOIs
StatePublished - Jul 19 1994

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Peroxisome Proliferator-Activated Receptors
Peroxisome Proliferators
Protein Isoforms
LY 171883
Linoleic Acid
Embryonic Development
Mammals
Fatty Acids
Complementary DNA

Keywords

  • β-oxidation
  • fatty acid
  • nuclear hormone receptors

ASJC Scopus subject areas

  • Genetics
  • General

Cite this

Differential expression and activation of a family of murine peroxisome proliferator-activated receptors. / Kliewer, S. A.; Forman, B. M.; Blumberg, B.; Ong, E. S.; Borgmeyer, U.; Mangelsdorf, D. J.; Umesono, K.; Evans, R. M.

In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 91, No. 15, 19.07.1994, p. 7355-7359.

Research output: Contribution to journalArticle

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