Differential reflex control of forearm and calf resistance vessels by chemosensitive cardiac afferent activation

T. N. Jacobsen, R. A. Lange, M. T. Olivari, C. W. Yancy, V. P H Horn, W. S. Ring, B. J. Baldwin, R. A. Cooley, R. G. Victor

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

The aim of this study was to determine whether chemosensitive ventricular afferent activation in humans evokes a diffuse pattern of reflex vasodilation involving the skeletal muscle circulation of all the extremities or a highly specified pattern of vasodilation that is limited to the rather small vascular bed of the forearm. In 10 patients with innervated ventricles and 7 patients with denervated ventricles resulting from heart transplantation, we performed simultaneous plethysmographic recordings of blood flow in the forearm and calf during chemosensitive ventricular afferent activation with intracoronary Renografin. In patients with innervated ventricles, intracoronary Renografin evoked directionally opposite vascular responses in the forearm and calf: forearm resistance decreased from 50 ± 11 to 31 ± 8 units, whereas calf resistance increased from 42 ± 7 to 59 ± 9 units (P < 0.05, calf vs. forearm). Forearm vasodilation was eliminated after heart transplantation, indicating that this is a reflex response caused by ventricular afferents. In contrast, calf vasoconstriction was well preserved despite ventricular deafferentation, indicating that this response is caused by mechanisms other than ventricular afferent activation, possibly the sinoaortic baroreceptors. Taken together, these findings document a remarkable degree of specificity in the effects of cardiac afferent activation on the reflex regulation of regional vasomotor tone in humans.

Original languageEnglish (US)
Pages (from-to)1123-1129
Number of pages7
JournalJournal of Applied Physiology
Volume76
Issue number3
StatePublished - 1994

Fingerprint

Forearm
Reflex
Vasodilation
Diatrizoate Meglumine
Heart Transplantation
Blood Vessels
Pressoreceptors
Vasoconstriction
Skeletal Muscle
Extremities

Keywords

  • Bezold-Jarisch reflex
  • heart transplant recipients
  • Renografin
  • sinoaortic baroreflexes
  • ventricular C-fibers

ASJC Scopus subject areas

  • Endocrinology
  • Physiology
  • Orthopedics and Sports Medicine
  • Physical Therapy, Sports Therapy and Rehabilitation

Cite this

Jacobsen, T. N., Lange, R. A., Olivari, M. T., Yancy, C. W., Horn, V. P. H., Ring, W. S., ... Victor, R. G. (1994). Differential reflex control of forearm and calf resistance vessels by chemosensitive cardiac afferent activation. Journal of Applied Physiology, 76(3), 1123-1129.

Differential reflex control of forearm and calf resistance vessels by chemosensitive cardiac afferent activation. / Jacobsen, T. N.; Lange, R. A.; Olivari, M. T.; Yancy, C. W.; Horn, V. P H; Ring, W. S.; Baldwin, B. J.; Cooley, R. A.; Victor, R. G.

In: Journal of Applied Physiology, Vol. 76, No. 3, 1994, p. 1123-1129.

Research output: Contribution to journalArticle

Jacobsen, TN, Lange, RA, Olivari, MT, Yancy, CW, Horn, VPH, Ring, WS, Baldwin, BJ, Cooley, RA & Victor, RG 1994, 'Differential reflex control of forearm and calf resistance vessels by chemosensitive cardiac afferent activation', Journal of Applied Physiology, vol. 76, no. 3, pp. 1123-1129.
Jacobsen, T. N. ; Lange, R. A. ; Olivari, M. T. ; Yancy, C. W. ; Horn, V. P H ; Ring, W. S. ; Baldwin, B. J. ; Cooley, R. A. ; Victor, R. G. / Differential reflex control of forearm and calf resistance vessels by chemosensitive cardiac afferent activation. In: Journal of Applied Physiology. 1994 ; Vol. 76, No. 3. pp. 1123-1129.
@article{c6f96fdf323c494c9f87262bea4502d2,
title = "Differential reflex control of forearm and calf resistance vessels by chemosensitive cardiac afferent activation",
abstract = "The aim of this study was to determine whether chemosensitive ventricular afferent activation in humans evokes a diffuse pattern of reflex vasodilation involving the skeletal muscle circulation of all the extremities or a highly specified pattern of vasodilation that is limited to the rather small vascular bed of the forearm. In 10 patients with innervated ventricles and 7 patients with denervated ventricles resulting from heart transplantation, we performed simultaneous plethysmographic recordings of blood flow in the forearm and calf during chemosensitive ventricular afferent activation with intracoronary Renografin. In patients with innervated ventricles, intracoronary Renografin evoked directionally opposite vascular responses in the forearm and calf: forearm resistance decreased from 50 ± 11 to 31 ± 8 units, whereas calf resistance increased from 42 ± 7 to 59 ± 9 units (P < 0.05, calf vs. forearm). Forearm vasodilation was eliminated after heart transplantation, indicating that this is a reflex response caused by ventricular afferents. In contrast, calf vasoconstriction was well preserved despite ventricular deafferentation, indicating that this response is caused by mechanisms other than ventricular afferent activation, possibly the sinoaortic baroreceptors. Taken together, these findings document a remarkable degree of specificity in the effects of cardiac afferent activation on the reflex regulation of regional vasomotor tone in humans.",
keywords = "Bezold-Jarisch reflex, heart transplant recipients, Renografin, sinoaortic baroreflexes, ventricular C-fibers",
author = "Jacobsen, {T. N.} and Lange, {R. A.} and Olivari, {M. T.} and Yancy, {C. W.} and Horn, {V. P H} and Ring, {W. S.} and Baldwin, {B. J.} and Cooley, {R. A.} and Victor, {R. G.}",
year = "1994",
language = "English (US)",
volume = "76",
pages = "1123--1129",
journal = "Journal of Applied Physiology",
issn = "0161-7567",
publisher = "American Physiological Society",
number = "3",

}

TY - JOUR

T1 - Differential reflex control of forearm and calf resistance vessels by chemosensitive cardiac afferent activation

AU - Jacobsen, T. N.

AU - Lange, R. A.

AU - Olivari, M. T.

AU - Yancy, C. W.

AU - Horn, V. P H

AU - Ring, W. S.

AU - Baldwin, B. J.

AU - Cooley, R. A.

AU - Victor, R. G.

PY - 1994

Y1 - 1994

N2 - The aim of this study was to determine whether chemosensitive ventricular afferent activation in humans evokes a diffuse pattern of reflex vasodilation involving the skeletal muscle circulation of all the extremities or a highly specified pattern of vasodilation that is limited to the rather small vascular bed of the forearm. In 10 patients with innervated ventricles and 7 patients with denervated ventricles resulting from heart transplantation, we performed simultaneous plethysmographic recordings of blood flow in the forearm and calf during chemosensitive ventricular afferent activation with intracoronary Renografin. In patients with innervated ventricles, intracoronary Renografin evoked directionally opposite vascular responses in the forearm and calf: forearm resistance decreased from 50 ± 11 to 31 ± 8 units, whereas calf resistance increased from 42 ± 7 to 59 ± 9 units (P < 0.05, calf vs. forearm). Forearm vasodilation was eliminated after heart transplantation, indicating that this is a reflex response caused by ventricular afferents. In contrast, calf vasoconstriction was well preserved despite ventricular deafferentation, indicating that this response is caused by mechanisms other than ventricular afferent activation, possibly the sinoaortic baroreceptors. Taken together, these findings document a remarkable degree of specificity in the effects of cardiac afferent activation on the reflex regulation of regional vasomotor tone in humans.

AB - The aim of this study was to determine whether chemosensitive ventricular afferent activation in humans evokes a diffuse pattern of reflex vasodilation involving the skeletal muscle circulation of all the extremities or a highly specified pattern of vasodilation that is limited to the rather small vascular bed of the forearm. In 10 patients with innervated ventricles and 7 patients with denervated ventricles resulting from heart transplantation, we performed simultaneous plethysmographic recordings of blood flow in the forearm and calf during chemosensitive ventricular afferent activation with intracoronary Renografin. In patients with innervated ventricles, intracoronary Renografin evoked directionally opposite vascular responses in the forearm and calf: forearm resistance decreased from 50 ± 11 to 31 ± 8 units, whereas calf resistance increased from 42 ± 7 to 59 ± 9 units (P < 0.05, calf vs. forearm). Forearm vasodilation was eliminated after heart transplantation, indicating that this is a reflex response caused by ventricular afferents. In contrast, calf vasoconstriction was well preserved despite ventricular deafferentation, indicating that this response is caused by mechanisms other than ventricular afferent activation, possibly the sinoaortic baroreceptors. Taken together, these findings document a remarkable degree of specificity in the effects of cardiac afferent activation on the reflex regulation of regional vasomotor tone in humans.

KW - Bezold-Jarisch reflex

KW - heart transplant recipients

KW - Renografin

KW - sinoaortic baroreflexes

KW - ventricular C-fibers

UR - http://www.scopus.com/inward/record.url?scp=0028356767&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0028356767&partnerID=8YFLogxK

M3 - Article

VL - 76

SP - 1123

EP - 1129

JO - Journal of Applied Physiology

JF - Journal of Applied Physiology

SN - 0161-7567

IS - 3

ER -