Differential regulation and properties of MAPKs

M. Raman, W. Chen, M. H. Cobb

Research output: Contribution to journalReview article

974 Scopus citations

Abstract

Mitogen-activated protein kinases (MAPKs) regulate diverse cellular programs including embryogenesis, proliferation, differentiation and apoptosis based on cues derived from the cell surface and the metabolic state and environment of the cell. In mammals, there are more than a dozen MAPK genes. The best known are the extracellular signal-regulated kinases 1 and 2 (ERK1/2), c-Jun N-terminal kinase (JNK(1-3)) and p38(α, β, γ and δ) families. ERK3, ERK5 and ERK7 are other MAPKs that have distinct regulation and functions. MAPK cascades consist of a core of three protein kinases. Despite the apparently simple architecture of this pathway, these enzymes are capable of responding to a bewildering number of stimuli to produce exquisitely specific cellular outcomes. These responses depend on the kinetics of their activation and inactivation, the subcellular localization of the kinases, the complexes in which they act, and the availability of substrates. Fine-tuning of cascade activity can occur through modulatory inputs to cascade component from the primary kinases to the scaffolding accessory proteins. Here, we describe some of the properties of the three major MAPK pathways and discuss how these properties govern pathway regulation and activity.

Original languageEnglish (US)
Pages (from-to)3100-3112
Number of pages13
JournalOncogene
Volume26
Issue number22
DOIs
StatePublished - May 14 2007

Keywords

  • ERK
  • JNK
  • Kinase
  • MAPK
  • Phosphorylation
  • p38

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Cancer Research

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