Differential susceptibility of neonatal and adult murine spleen cells to in vitro induction of b-cell tolerance*

J. C. Cambier, J. R. Kettman, E. S. Vitetta, J. W. Uhr

Research output: Contribution to journalArticle

98 Scopus citations

Abstract

The relative susceptibility of neonatal and adult murine splenocytes to induction of B-cell tolerance was studied in vitro. Adult cells required approximately 1,000-fold more trinitrophenyl-human gamma globulin to be rendered tolerant than did cells from 9- to 12-day-old neonates. The potential effects of suppressor T cells were excluded by pretreating the cultured B cells with anti-Thy-1 and C’ and the helper T cells with anti-Ly-2.2 and C’. The possible role of cell surface immunoglobulin isotypes in contributing to this observed difference is discussed.

Original languageEnglish (US)
Pages (from-to)293-297
Number of pages5
JournalJournal of Experimental Medicine
Volume144
Issue number1
DOIs
StatePublished - Jul 1 1976

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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