Abstract
The relative susceptibility of neonatal and adult murine splenocytes to induction of B-cell tolerance was studied in vitro. Adult cells required approximately 1,000-fold more trinitrophenyl-human gamma globulin to be rendered tolerant than did cells from 9- to 12-day-old neonates. The potential effects of suppressor T cells were excluded by pretreating the cultured B cells with anti-Thy-1 and C’ and the helper T cells with anti-Ly-2.2 and C’. The possible role of cell surface immunoglobulin isotypes in contributing to this observed difference is discussed.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 293-297 |
| Number of pages | 5 |
| Journal | Journal of Experimental Medicine |
| Volume | 144 |
| Issue number | 1 |
| DOIs | |
| State | Published - Jul 1 1976 |
ASJC Scopus subject areas
- Immunology and Allergy
- Immunology