TY - JOUR
T1 - Differentiating congenital ovarian cysts from other abdominal cystic lesions in female infants
T2 - A study by the Canadian Consortium for Research in Pediatric Surgery (CanCORPS)
AU - Safa, Nadia
AU - Yanchar, Natalie
AU - Puligandla, Pramod
AU - Sewitch, Maida
AU - Baird, Robert
AU - Beaunoyer, Mona
AU - Butter, Andreana
AU - Campbell, Niamh
AU - Chadha, Rati
AU - Griffiths, Christopher
AU - Jones, Sarah
AU - Kaur, Manvinder
AU - Le-Nguyen, Annie
AU - Nasr, Ahmed
AU - Piché, Nelson
AU - Piper, Hannah
AU - Prasil, Pascale
AU - Romao, Rodrigo
AU - VanHouwelingen, Lisa
AU - Wales, Paul
AU - Guadagno, Elena
AU - Emil, Sherif
AU - for the Canadian Consortium for Research in Pediatric Surgery (CanCORPS), the Canadian Consortium for Research in Pediatric Surgery (CanCORPS)
N1 - Publisher Copyright:
© 2022
PY - 2022/5
Y1 - 2022/5
N2 - Purpose: The origin of congenital abdominal cysts in the female fetus often dictates management. While most arise from the ovary and are often managed non-operatively, some are non-ovarian and are frequently removed. We analyzed a national sample of female infants with congenital abdominal cysts to elucidate prenatal and postnatal factors associated with the diagnosis of a non-ovarian cyst. Methods: A retrospective cohort study of female infants who were prenatally diagnosed with abdominal cysts between 2013 and 2017 at 10 Canadian pediatric surgical centres was performed. Clinical characteristics, pre- and postnatal sonographic findings, and cyst trajectories were compared between patients with proven ovarian etiology and those with cysts arising from other organs. Results: Of 185 infants with prenatally diagnosed abdominal cysts, 22 (12%) were non-ovarian, five of which had clear non-ovarian organ of origin on prenatal ultrasound. Comparison of the other 17 cysts with 163 congenital ovarian cysts showed the following factors to be associated with a non-ovarian origin: earlier gestational age at diagnosis (23.5 vs 33.5 weeks, p <0.001), smaller diameter on first prenatal ultrasound (15.8 vs. 39.7 mm, p <0.001), change in sonographic character from simple to complex (87% vs 22%, p <0.001), and postnatal sonographic characteristics of complex cyst (87% vs. 48%, p = 0.004). Conclusion: Clear organ of origin, diagnosis earlier in gestation, smaller initial prenatal cyst diameter, and sonographic cyst character change differentiate congenital non-ovarian cysts from their ovarian counterparts. These characteristics may be used to guide diagnosis and management.
AB - Purpose: The origin of congenital abdominal cysts in the female fetus often dictates management. While most arise from the ovary and are often managed non-operatively, some are non-ovarian and are frequently removed. We analyzed a national sample of female infants with congenital abdominal cysts to elucidate prenatal and postnatal factors associated with the diagnosis of a non-ovarian cyst. Methods: A retrospective cohort study of female infants who were prenatally diagnosed with abdominal cysts between 2013 and 2017 at 10 Canadian pediatric surgical centres was performed. Clinical characteristics, pre- and postnatal sonographic findings, and cyst trajectories were compared between patients with proven ovarian etiology and those with cysts arising from other organs. Results: Of 185 infants with prenatally diagnosed abdominal cysts, 22 (12%) were non-ovarian, five of which had clear non-ovarian organ of origin on prenatal ultrasound. Comparison of the other 17 cysts with 163 congenital ovarian cysts showed the following factors to be associated with a non-ovarian origin: earlier gestational age at diagnosis (23.5 vs 33.5 weeks, p <0.001), smaller diameter on first prenatal ultrasound (15.8 vs. 39.7 mm, p <0.001), change in sonographic character from simple to complex (87% vs 22%, p <0.001), and postnatal sonographic characteristics of complex cyst (87% vs. 48%, p = 0.004). Conclusion: Clear organ of origin, diagnosis earlier in gestation, smaller initial prenatal cyst diameter, and sonographic cyst character change differentiate congenital non-ovarian cysts from their ovarian counterparts. These characteristics may be used to guide diagnosis and management.
KW - Fetal
KW - Intra-abdominal cyst
KW - Ovarian cyst
KW - Postnatal outcome
KW - Prenatal diagnosis
KW - Prenatal ultrasound
UR - http://www.scopus.com/inward/record.url?scp=85123569844&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85123569844&partnerID=8YFLogxK
U2 - 10.1016/j.jpedsurg.2021.12.043
DO - 10.1016/j.jpedsurg.2021.12.043
M3 - Article
C2 - 35090716
AN - SCOPUS:85123569844
SN - 0022-3468
VL - 57
SP - 877
EP - 882
JO - Journal of Pediatric Surgery
JF - Journal of Pediatric Surgery
IS - 5
ER -