Differentiating social preference and social anxiety phenotypes in fragile X syndrome using an eye gaze analysis

a pilot study

Michael P. Hong, Eleanor M. Eckert, Ernest V. Pedapati, Rebecca C. Shaffer, Kelli C. Dominick, Logan K. Wink, John A Sweeney, Craig A. Erickson

Research output: Contribution to journalArticle

Abstract

BACKGROUND: Fragile X syndrome (FXS) is the leading inherited cause of autism spectrum disorder, but there remains debate regarding the clinical presentation of social deficits in FXS. The aim of this study was to compare individuals with FXS to typically developing controls (TDC) and individuals with idiopathic autism spectrum disorder (ASD) across two social eye tracking paradigms. METHODS: Individuals with FXS and age- and gender-matched TDC and individuals with idiopathic ASD completed emotional face and social preference eye tracking tasks to evaluate gaze aversion and social interest, respectively. Participants completed a battery of cognitive testing and caregiver-reported measures for neurobehavioral characterization. RESULTS: Individuals with FXS exhibited reduced eye and increased mouth gaze to emotional faces compared to TDC. Gaze aversive findings were found to correlate with measures of anxiety, social communication deficits, and behavioral problems. In the social interest task, while individuals with idiopathic ASD showed significantly less social preference, individuals with FXS displayed social preference similar to TDC. CONCLUSIONS: These findings suggest fragile X syndrome social deficits center on social anxiety without the prominent reduction in social interest associated with autism spectrum disorder. Specifically designed eye tracking techniques clarify the nature of social deficits in fragile X syndrome and may have applications to improve phenotyping and evaluate interventions targeting social functioning impairments.

Original languageEnglish (US)
Number of pages1
JournalJournal of Neurodevelopmental Disorders
Volume11
Issue number1
DOIs
StatePublished - Jan 21 2019
Externally publishedYes

Fingerprint

Fragile X Syndrome
Anxiety
Phenotype
Caregivers
Mouth
Communication
Autism Spectrum Disorder

Keywords

  • Autism
  • Eye tracking
  • Fragile X syndrome
  • Gaze aversion
  • Social anxiety
  • Social interest

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Pathology and Forensic Medicine
  • Clinical Neurology
  • Cognitive Neuroscience

Cite this

Differentiating social preference and social anxiety phenotypes in fragile X syndrome using an eye gaze analysis : a pilot study. / Hong, Michael P.; Eckert, Eleanor M.; Pedapati, Ernest V.; Shaffer, Rebecca C.; Dominick, Kelli C.; Wink, Logan K.; Sweeney, John A; Erickson, Craig A.

In: Journal of Neurodevelopmental Disorders, Vol. 11, No. 1, 21.01.2019.

Research output: Contribution to journalArticle

Hong, Michael P. ; Eckert, Eleanor M. ; Pedapati, Ernest V. ; Shaffer, Rebecca C. ; Dominick, Kelli C. ; Wink, Logan K. ; Sweeney, John A ; Erickson, Craig A. / Differentiating social preference and social anxiety phenotypes in fragile X syndrome using an eye gaze analysis : a pilot study. In: Journal of Neurodevelopmental Disorders. 2019 ; Vol. 11, No. 1.
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