TY - JOUR
T1 - Diffuse alveolar hemorrhage with underlying pulmonary capillaritis in the retinoic acid syndrome
AU - Nicolls, Mark R.
AU - Terada, Lance S.
AU - Tuder, Rubin M.
AU - Prindiville, Sheila A.
AU - Schwarz, Marvin I.
PY - 1998
Y1 - 1998
N2 - All-trans-retinoic acid (ATRA) can induce a clinical remission in patients with acute promyelocytic leukemia. An adverse condition called 'retinoic acid syndrome' limits this therapy. It is characterized by fever and respiratory distress, along with weight gain, pleural or pericardial effusions, peripheral edema, thromboembolic events, and intermittent hypotension. The lung disease has been previously ascribed to an infiltration of leukemic or maturing myeloid cells into lung parenchyma, which is sometimes associated with pleural effusions and diffuse alveolar hemorrhage. We report a case of retinoic acid syndrome in an 18-yr-old woman who developed diffuse alveolar hemorrhage while being treated with ATRA for acute promyelocytic leukemia. An open lung biopsy revealed pulmonary capillaritis.
AB - All-trans-retinoic acid (ATRA) can induce a clinical remission in patients with acute promyelocytic leukemia. An adverse condition called 'retinoic acid syndrome' limits this therapy. It is characterized by fever and respiratory distress, along with weight gain, pleural or pericardial effusions, peripheral edema, thromboembolic events, and intermittent hypotension. The lung disease has been previously ascribed to an infiltration of leukemic or maturing myeloid cells into lung parenchyma, which is sometimes associated with pleural effusions and diffuse alveolar hemorrhage. We report a case of retinoic acid syndrome in an 18-yr-old woman who developed diffuse alveolar hemorrhage while being treated with ATRA for acute promyelocytic leukemia. An open lung biopsy revealed pulmonary capillaritis.
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U2 - 10.1164/ajrccm.158.4.9709085
DO - 10.1164/ajrccm.158.4.9709085
M3 - Article
C2 - 9769296
AN - SCOPUS:0031796540
SN - 1073-449X
VL - 158
SP - 1302
EP - 1305
JO - American journal of respiratory and critical care medicine
JF - American journal of respiratory and critical care medicine
IS - 4
ER -