Diffuse Correlation Spectroscopy Analysis Implemented on a Field Programmable Gate Array

Wei Lin, David R. Busch, Chia Chieh Goh, James Barsi, Thomas F. Floyd

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

Diffusive correlation spectroscopy (DCS) is an emerging optical technique that measures blood perfusion in deep tissue. In a DCS measurement, temporal changes in the interference pattern of light, which has passed through tissue, are quantified by an autocorrelation function. This autocorrelation function is further parameterized through a non-linear curve fit to a solution to the diffusion equation for coherence transport. The computational load for this non-linear curve fitting is a barrier for deployment of DCS for clinical use, where real-time results, as well as instrument size and simplicity, are important considerations. We have mitigated this computational bottleneck through development of a hardware analyzer for DCS. This analyzer implements the DCS curving fitting algorithm on digital logic circuit using Field Programmable Gate Array (FPGA) technology. The FPGA analyzer is more efficient than a typical software analysis solution. The analyzer module can be easily duplicated for processing multiple channels of DCS data in real-time. We have demonstrated the utility of this analyzer in pre-clinical large animal studies of spinal cord ischemia. In combination with previously described FPGA implementations of auto-correlators, this hardware analyzer can provide a complete device-on-a-chip solution for DCS signal processing. Such a component will enable new DCS applications demanding mobility and real-time processing.

Original languageEnglish (US)
Article number8817970
Pages (from-to)122503-122512
Number of pages10
JournalIEEE Access
Volume7
DOIs
StatePublished - 2019

Keywords

  • High performance computing
  • diffuse correlation spectroscopy
  • field programmable gate array

ASJC Scopus subject areas

  • Computer Science(all)
  • Materials Science(all)
  • Engineering(all)

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