Diffusion Tensor Imaging Study of White Matter Fiber Tracts in Pediatric Bipolar Disorder and Attention-Deficit/Hyperactivity Disorder

Mani N. Pavuluri, Shuohui Yang, Kiran Kamineni, Alessandra M. Passarotti, Girish Srinivasan, Erin M. Harral, John A. Sweeney, Xiaohong Joe Zhou

Research output: Contribution to journalArticle

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Abstract

Background: To investigate microstructure of white matter fiber tracts in pediatric bipolar disorder (PBD) and attention-deficit/hyperactivity disorder (ADHD). Methods: A diffusion tensor imaging (DTI) study was conducted at 3 Tesla on age- and IQ-matched children and adolescents with PBD (n = 13), ADHD (n = 13), and healthy control subjects (HC) (n = 15). Three DTI parameters, fractional anisotropy (FA), apparent diffusion coefficient (ADC), and regional fiber coherence index (r-FCI), were examined in eight fiber tracts: anterior corona radiata (ACR), anterior limb of the internal capsule (ALIC), superior region of the internal capsule (SRI), posterior limb of the internal capsule (PLIC), superior longitudinal fasciculus (SLF), inferior longitudinal fasciculus (ILF), cingulum (CG), and splenium (SP). Results: Significantly lower FA was observed in ACR in both PBD and ADHD relative to HC. In addition, FA and r-FCI values were significantly lower in ADHD relative to PBD and HC in both the ALIC and the SRI. Further, ADC was significantly greater in ADHD relative to both the PBD and HC in ACR, ALIC, PLIC, SRI, CG, ILF, and SLF. Conclusions: Decreased FA in ACR implies an impaired fiber density or reduced myelination in both PBD and ADHD in this prefrontal tract. These abnormalities, together with the reduced fiber coherence, extended to corticobulbar tracts in ADHD. Increased ADC across multiple white matter tracts in ADHD indicates extensive cellular abnormalities with less diffusion restriction in ADHD relative to PBD.

Original languageEnglish (US)
Pages (from-to)586-593
Number of pages8
JournalBiological Psychiatry
Volume65
Issue number7
DOIs
StatePublished - Apr 1 2009

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Diffusion Tensor Imaging
Internal Capsule
Attention Deficit Disorder with Hyperactivity
Bipolar Disorder
Pediatrics
Anisotropy
Extremities
Healthy Volunteers
White Matter
Pyramidal Tracts

Keywords

  • ADHD
  • apparent diffusion coefficients
  • bipolar disorder
  • diffusion tensor imaging
  • fraction anisotropy
  • white matter fiber tracts

ASJC Scopus subject areas

  • Biological Psychiatry

Cite this

Pavuluri, M. N., Yang, S., Kamineni, K., Passarotti, A. M., Srinivasan, G., Harral, E. M., ... Zhou, X. J. (2009). Diffusion Tensor Imaging Study of White Matter Fiber Tracts in Pediatric Bipolar Disorder and Attention-Deficit/Hyperactivity Disorder. Biological Psychiatry, 65(7), 586-593. https://doi.org/10.1016/j.biopsych.2008.10.015

Diffusion Tensor Imaging Study of White Matter Fiber Tracts in Pediatric Bipolar Disorder and Attention-Deficit/Hyperactivity Disorder. / Pavuluri, Mani N.; Yang, Shuohui; Kamineni, Kiran; Passarotti, Alessandra M.; Srinivasan, Girish; Harral, Erin M.; Sweeney, John A.; Zhou, Xiaohong Joe.

In: Biological Psychiatry, Vol. 65, No. 7, 01.04.2009, p. 586-593.

Research output: Contribution to journalArticle

Pavuluri, MN, Yang, S, Kamineni, K, Passarotti, AM, Srinivasan, G, Harral, EM, Sweeney, JA & Zhou, XJ 2009, 'Diffusion Tensor Imaging Study of White Matter Fiber Tracts in Pediatric Bipolar Disorder and Attention-Deficit/Hyperactivity Disorder', Biological Psychiatry, vol. 65, no. 7, pp. 586-593. https://doi.org/10.1016/j.biopsych.2008.10.015
Pavuluri, Mani N. ; Yang, Shuohui ; Kamineni, Kiran ; Passarotti, Alessandra M. ; Srinivasan, Girish ; Harral, Erin M. ; Sweeney, John A. ; Zhou, Xiaohong Joe. / Diffusion Tensor Imaging Study of White Matter Fiber Tracts in Pediatric Bipolar Disorder and Attention-Deficit/Hyperactivity Disorder. In: Biological Psychiatry. 2009 ; Vol. 65, No. 7. pp. 586-593.
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AU - Yang, Shuohui

AU - Kamineni, Kiran

AU - Passarotti, Alessandra M.

AU - Srinivasan, Girish

AU - Harral, Erin M.

AU - Sweeney, John A.

AU - Zhou, Xiaohong Joe

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N2 - Background: To investigate microstructure of white matter fiber tracts in pediatric bipolar disorder (PBD) and attention-deficit/hyperactivity disorder (ADHD). Methods: A diffusion tensor imaging (DTI) study was conducted at 3 Tesla on age- and IQ-matched children and adolescents with PBD (n = 13), ADHD (n = 13), and healthy control subjects (HC) (n = 15). Three DTI parameters, fractional anisotropy (FA), apparent diffusion coefficient (ADC), and regional fiber coherence index (r-FCI), were examined in eight fiber tracts: anterior corona radiata (ACR), anterior limb of the internal capsule (ALIC), superior region of the internal capsule (SRI), posterior limb of the internal capsule (PLIC), superior longitudinal fasciculus (SLF), inferior longitudinal fasciculus (ILF), cingulum (CG), and splenium (SP). Results: Significantly lower FA was observed in ACR in both PBD and ADHD relative to HC. In addition, FA and r-FCI values were significantly lower in ADHD relative to PBD and HC in both the ALIC and the SRI. Further, ADC was significantly greater in ADHD relative to both the PBD and HC in ACR, ALIC, PLIC, SRI, CG, ILF, and SLF. Conclusions: Decreased FA in ACR implies an impaired fiber density or reduced myelination in both PBD and ADHD in this prefrontal tract. These abnormalities, together with the reduced fiber coherence, extended to corticobulbar tracts in ADHD. Increased ADC across multiple white matter tracts in ADHD indicates extensive cellular abnormalities with less diffusion restriction in ADHD relative to PBD.

AB - Background: To investigate microstructure of white matter fiber tracts in pediatric bipolar disorder (PBD) and attention-deficit/hyperactivity disorder (ADHD). Methods: A diffusion tensor imaging (DTI) study was conducted at 3 Tesla on age- and IQ-matched children and adolescents with PBD (n = 13), ADHD (n = 13), and healthy control subjects (HC) (n = 15). Three DTI parameters, fractional anisotropy (FA), apparent diffusion coefficient (ADC), and regional fiber coherence index (r-FCI), were examined in eight fiber tracts: anterior corona radiata (ACR), anterior limb of the internal capsule (ALIC), superior region of the internal capsule (SRI), posterior limb of the internal capsule (PLIC), superior longitudinal fasciculus (SLF), inferior longitudinal fasciculus (ILF), cingulum (CG), and splenium (SP). Results: Significantly lower FA was observed in ACR in both PBD and ADHD relative to HC. In addition, FA and r-FCI values were significantly lower in ADHD relative to PBD and HC in both the ALIC and the SRI. Further, ADC was significantly greater in ADHD relative to both the PBD and HC in ACR, ALIC, PLIC, SRI, CG, ILF, and SLF. Conclusions: Decreased FA in ACR implies an impaired fiber density or reduced myelination in both PBD and ADHD in this prefrontal tract. These abnormalities, together with the reduced fiber coherence, extended to corticobulbar tracts in ADHD. Increased ADC across multiple white matter tracts in ADHD indicates extensive cellular abnormalities with less diffusion restriction in ADHD relative to PBD.

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KW - fraction anisotropy

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