Diffusion-weighted MR imaging of the gastrointestinal tract: Technique, indications, and imaging findings

Rakesh Sinha, Prabhakar Rajiah, Iswaran Ramachandran, Scott Sanders, Paul D. Murphy

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

Diffusion-weighted magnetic resonance (MR) imaging has emerged as an important tool in the diagnostic work-up of patients with bowel cancer and inflammatory conditions of the gastrointestinal tract. It functions on the basis of the microscopic motion of water molecules in a cellular environment and provides functional information about the water in body tissues. Diffusion-weighted imaging serves to complement conventional MR imaging, and its use may improve the accuracy of tumor detection and staging. It does not rely on the use of intravenous contrast material and may be performed in patients with renal impairment. Because it provides quantitative information about tissue cellularity, diffusion-weighted imaging may be used to distinguish between tissues with altered cellularity (eg, tumors and metastases) and normal tissues. Data from diffusion-weighted MR images enable the calculation of apparent diffusion coefficient (ADC) values, which provide useful information about response to treatment. Malignant gastrointestinal tract tumors have low ADC values, which increase after successful therapy. Diffusion-weighted imaging also plays a role in the evaluation of patients with inflammatory bowel disease and may help assess inflammation and complications, such as abscesses and fistulas. Quantitative measurements of signal intensity at diffusion-weighted imaging may help differentiate actively inflamed bowel from normal bowel, and ADC values provide useful information about disease activity and response to treatment.

Original languageEnglish (US)
Pages (from-to)655-676
Number of pages22
JournalRadiographics
Volume33
Issue number3
DOIs
StatePublished - May 1 2013

Fingerprint

Diffusion Magnetic Resonance Imaging
Gastrointestinal Tract
Body Water
Neoplasm Staging
Inflammatory Bowel Diseases
Colonic Neoplasms
Abscess
Contrast Media
Fistula
Neoplasms
Magnetic Resonance Spectroscopy
Therapeutics
Magnetic Resonance Imaging
Neoplasm Metastasis
Inflammation
Kidney
Water

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

Diffusion-weighted MR imaging of the gastrointestinal tract : Technique, indications, and imaging findings. / Sinha, Rakesh; Rajiah, Prabhakar; Ramachandran, Iswaran; Sanders, Scott; Murphy, Paul D.

In: Radiographics, Vol. 33, No. 3, 01.05.2013, p. 655-676.

Research output: Contribution to journalArticle

Sinha, R, Rajiah, P, Ramachandran, I, Sanders, S & Murphy, PD 2013, 'Diffusion-weighted MR imaging of the gastrointestinal tract: Technique, indications, and imaging findings', Radiographics, vol. 33, no. 3, pp. 655-676. https://doi.org/10.1148/rg.333125042
Sinha, Rakesh ; Rajiah, Prabhakar ; Ramachandran, Iswaran ; Sanders, Scott ; Murphy, Paul D. / Diffusion-weighted MR imaging of the gastrointestinal tract : Technique, indications, and imaging findings. In: Radiographics. 2013 ; Vol. 33, No. 3. pp. 655-676.
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