Digesting oneself and digesting microbes: Autophagy as a host response to viral infection

Montrell Seay, Savithramma Dinesh-Kumar, Beth Levine

Research output: Chapter in Book/Report/Conference proceedingChapter

11 Citations (Scopus)

Abstract

Conclusions: Although research in this area is still in a stage of infancy, it seems likely that the lysosomal degradation pathway of autophagy plays an evolutionarily conserved role in antiviral immunity. The interferon-inducible, antiviral PKR signaling pathway positively regulates autophagy, and both mammalian and plant autophagy genes restrict viral replication and protect against virus-induced cell death. Given this role of autophagy in innate immunity, it is not surprising that viruses have evolved numerous strategies to inhibit host autophagy. Different viral gene products can either modulate autophagy regulatory signals or directly interact with components of the autophagy execution machinery. Moreover, certain RNA viruses have managed to co-apt the autophagy pathway, selectively utilizing certain components of the dynamic membrane rearrangement system to promote their own replication inside the host cytoplasm. In addition to this newly emerging role of autophagy in innate immunity, autophagy plays an important role in many other fundamental biological processes, including tissue homeostasis, differentiation and development, cell growth control, and the prevention of aging. Accordingly, the inhibition of host autophagy by viral gene products has important implications not only for understanding mechanisms of immune evasion, but also for understanding novel mechanisms of viral pathogenesis. It will be interesting to dissect the role of viral inhibition of autophagy in acute, persistent, and latent viral replication, as well as in the pathogenesis of cancer and other medical diseases.

Original languageEnglish (US)
Title of host publicationModulation of Host Gene Expression and Innate Immunity by Viruses
PublisherSpringer Netherlands
Pages245-279
Number of pages35
ISBN (Print)9781402032424, 1402032412, 9781402032417
DOIs
StatePublished - 2005

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Autophagy
Virus Diseases
Viral Proteins
Innate Immunity
Antiviral Agents
Viruses
Biological Phenomena
Immune Evasion
Plant Genes
RNA Viruses
Growth and Development
Interferons
Cell Differentiation
Immunity
Cytoplasm
Homeostasis
Cell Death

ASJC Scopus subject areas

  • Immunology and Microbiology(all)

Cite this

Seay, M., Dinesh-Kumar, S., & Levine, B. (2005). Digesting oneself and digesting microbes: Autophagy as a host response to viral infection. In Modulation of Host Gene Expression and Innate Immunity by Viruses (pp. 245-279). Springer Netherlands. https://doi.org/10.1007/1-4020-3242-0_11

Digesting oneself and digesting microbes : Autophagy as a host response to viral infection. / Seay, Montrell; Dinesh-Kumar, Savithramma; Levine, Beth.

Modulation of Host Gene Expression and Innate Immunity by Viruses. Springer Netherlands, 2005. p. 245-279.

Research output: Chapter in Book/Report/Conference proceedingChapter

Seay, M, Dinesh-Kumar, S & Levine, B 2005, Digesting oneself and digesting microbes: Autophagy as a host response to viral infection. in Modulation of Host Gene Expression and Innate Immunity by Viruses. Springer Netherlands, pp. 245-279. https://doi.org/10.1007/1-4020-3242-0_11
Seay M, Dinesh-Kumar S, Levine B. Digesting oneself and digesting microbes: Autophagy as a host response to viral infection. In Modulation of Host Gene Expression and Innate Immunity by Viruses. Springer Netherlands. 2005. p. 245-279 https://doi.org/10.1007/1-4020-3242-0_11
Seay, Montrell ; Dinesh-Kumar, Savithramma ; Levine, Beth. / Digesting oneself and digesting microbes : Autophagy as a host response to viral infection. Modulation of Host Gene Expression and Innate Immunity by Viruses. Springer Netherlands, 2005. pp. 245-279
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