Digital karyotyping identifies thymidylate synthase amplification as a mechanism of resistance to 5-fluorouracil in metastatic colorectal cancer patients

Tian Li Wang, Luis A. Diaz, Katharine Romans, Alberto Bardelli, Saurabh Saha, Gennaro Galizia, Michael Choti, Ross Donehower, Giovanni Parmigiani, Ie Ming Shih, Christine Iacobuzio-Donahue, Kenneth W. Kinzler, Bert Vogelstein, Christoph Lengauer, Victor E. Velculescu