DILI: New insights into diagnosis and management

Thanh Tran; William M. Lee

doi:10.1007/s11901-012-0159-x

DILI: New insights into diagnosis and management

Thanh Tran, William M. Lee

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

Drug-induced liver injury continues to have a significant impact. With over 1000 drugs now registered as causing DILI, this form of liver injury is the most cited reason for withdrawal of a drug from the marketplace. Despite this, the diagnosis of DILI continues to rely on subjective measures and expert opinion with results that are both difficult to verify and reproduce. However, recent developments in DILI research may provide new insights to improve diagnosis and treatment in the future.

Original language	English (US)
Pages (from-to)	53-58
Number of pages	6
Journal	Current Hepatitis Reports
Volume	12
Issue number	1
DOIs	https://doi.org/10.1007/s11901-012-0159-x
State	Published - Mar 2013

Keywords

Acetaminophen
Biotransformation
Genetic polymorphism
Genome wide association study
Herbal and dietary supplements

ASJC Scopus subject areas

Hepatology
Virology

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10.1007/s11901-012-0159-x

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AB - Drug-induced liver injury continues to have a significant impact. With over 1000 drugs now registered as causing DILI, this form of liver injury is the most cited reason for withdrawal of a drug from the marketplace. Despite this, the diagnosis of DILI continues to rely on subjective measures and expert opinion with results that are both difficult to verify and reproduce. However, recent developments in DILI research may provide new insights to improve diagnosis and treatment in the future.

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KW - Herbal and dietary supplements

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DILI: New insights into diagnosis and management

Abstract

Keywords

ASJC Scopus subject areas

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