Dimethyl fumarate in relapsing-remitting multiple sclerosis: Rationale, mechanisms of action, pharmacokinetics, efficacy and safety

Duvyanshu Dubey, Bernd C. Kieseier, Hans P. Hartung, Bernhard Hemmer, Clemens Warnke, Til Menge, William A. Miller-Little, Olaf Stuve

Research output: Contribution to journalReview article

40 Scopus citations

Abstract

Dimethyl fumarate (DMF), a fumaric acid ester, is a new orally available disease-modifying agent that was recently approved by the US FDA and the EMA for the management of relapsing forms of multiple sclerosis (MS). Fumaric acid has been used for the management of psoriasis, for more than 50 years. Because of the known anti-inflammatory properties of fumaric acid ester, DMF was brought into clinical development in MS. More recently, neuroprotective and myelin-protective mechanism actions have been proposed, making it a possible candidate for MS treatment. Two Phase III clinical trials (DEFINE, CONFIRM) have evaluated the safety and efficacy of DMF in patients with relapsing-remitting MS. Being an orally available agent with a favorable safety profile, it has become one of the most commonly prescribed disease-modifying agents in the USA and Europe.

Original languageEnglish (US)
Pages (from-to)339-346
Number of pages8
JournalExpert review of neurotherapeutics
Volume15
Issue number4
DOIs
StatePublished - Apr 1 2015

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Keywords

  • dimethyl fumarate
  • experimental autoimmune encephalomyelitis
  • immunology
  • multiple sclerosis
  • pharmacology

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Neurology
  • Pharmacology (medical)

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