TY - JOUR
T1 - Diminished alveolar microvascular reserves in type 2 diabetes reflect systemic microangiopathy
AU - Chance, William W.
AU - Rhee, Chanhaeng
AU - Yilmaz, Cuneyt
AU - Dane, D. Merrill
AU - Pruneda, M. Lourdes
AU - Raskin, Philip
AU - Hsia, Connie C W
PY - 2008/8
Y1 - 2008/8
N2 - OBJECTIVE -Alveolar microvascular function is moderately impaired in type 1 diabetes, as manifested by restriction of lung volume and diffusing capacity (DL CO). We examined whether similar impairment develops in type 2 diabetes and defined the physiologic sources of impairment as well as the relationships to glycemia and systemic microangiopathy. RESEARCH DESIGN AND METHODS - A cross-sectional study was conducted at a university-affiliated diabetes treatment center and outpatient diabetes clinic, involving 69 nonsmoking type 2 diabetic patients without overt cardiopulmonary disease. Lung volume, pulmonary blood flow (Q), DL CO, membrane diffusing capacity (measured from nitric oxide uptake [DL NO]), and pulmonary capillary blood volume (V C) were determined at rest and exercise for comparison with those in 45 healthy nonsmokers as well as with normal reference values. RESULTS - In type 2 diabetic patients, peak levels of oxygen uptake, Q and DL CO,DL NO, and V C at exercise were 10-25% lower compared with those in control subjects. In nonobese patients (BMI <30 kg/m 2), reductions in DL CO,DL NO, and V C were fully explained by the lower lung volume and peak Q, but these factors did not fully explain the impairment in obese patients (BMI >30 kg/m 2). The slope of the increase in V C with respect to Q was reduced ∼20% in patients regardless of BMI, consistent with impaired alveolar-capillary recruitment. Functional impairment was directly related to A1C level, retinopathy, neuropathy, and microalbuminuria in a sex-specific manner. CONCLUSIONS - Alveolar microvascular reserves are reduced in type 2 diabetes, reflecting restriction of lung volume, alveolar perfusion, and capillary recruitment. This reduction correlates with glycemic control and extrapulmonary microangiopathy and is aggravated by obesity.
AB - OBJECTIVE -Alveolar microvascular function is moderately impaired in type 1 diabetes, as manifested by restriction of lung volume and diffusing capacity (DL CO). We examined whether similar impairment develops in type 2 diabetes and defined the physiologic sources of impairment as well as the relationships to glycemia and systemic microangiopathy. RESEARCH DESIGN AND METHODS - A cross-sectional study was conducted at a university-affiliated diabetes treatment center and outpatient diabetes clinic, involving 69 nonsmoking type 2 diabetic patients without overt cardiopulmonary disease. Lung volume, pulmonary blood flow (Q), DL CO, membrane diffusing capacity (measured from nitric oxide uptake [DL NO]), and pulmonary capillary blood volume (V C) were determined at rest and exercise for comparison with those in 45 healthy nonsmokers as well as with normal reference values. RESULTS - In type 2 diabetic patients, peak levels of oxygen uptake, Q and DL CO,DL NO, and V C at exercise were 10-25% lower compared with those in control subjects. In nonobese patients (BMI <30 kg/m 2), reductions in DL CO,DL NO, and V C were fully explained by the lower lung volume and peak Q, but these factors did not fully explain the impairment in obese patients (BMI >30 kg/m 2). The slope of the increase in V C with respect to Q was reduced ∼20% in patients regardless of BMI, consistent with impaired alveolar-capillary recruitment. Functional impairment was directly related to A1C level, retinopathy, neuropathy, and microalbuminuria in a sex-specific manner. CONCLUSIONS - Alveolar microvascular reserves are reduced in type 2 diabetes, reflecting restriction of lung volume, alveolar perfusion, and capillary recruitment. This reduction correlates with glycemic control and extrapulmonary microangiopathy and is aggravated by obesity.
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U2 - 10.2337/dc07-2323
DO - 10.2337/dc07-2323
M3 - Article
C2 - 18492945
AN - SCOPUS:49649113482
SN - 0149-5992
VL - 31
SP - 1596
EP - 1601
JO - Diabetes care
JF - Diabetes care
IS - 8
ER -