Abstract
The results of multiple investigations indicate visual motion-processing abnormalities in schizophrenia. There is little information, however, about the time course and neural correlates of motion-processing abnormalities among these subjects. For the present study, 13 schizophrenia and 13 healthy subjects performed a simple motion direction discrimination task with peripherally presented moving grating stimuli (5 or 10 deg/s). Dense-array electroencephalography data were collected simultaneously. The goal was to discern whether neural deviations associated with motion-processing abnormalities among schizophrenia patients occur early or late in the visual-processing stream. Schizophrenia patients were worse at judging the direction of motion gratings, had enhanced early neural activity (about 90 ms after stimulus onset), and deficient target detection-related late neural activity over parietal cortex (about 400 ms after stimulus onset). In addition, there was a strong association (accounting for 36% of performance variance) between poor behavioral performance and lower target detection-related brain activity among schizophrenia patients. These findings suggest that abnormalities in later stages of motion-processing mechanisms, perhaps beyond extrastriate cortex, may account for behavioral deviations among schizophrenia subjects.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1749-1755 |
| Number of pages | 7 |
| Journal | Cerebral Cortex |
| Volume | 20 |
| Issue number | 7 |
| DOIs | |
| State | Published - Jul 2010 |
Fingerprint
Keywords
- ERP
- motion
- motion processing
- P1
- parietal cortex
- schizophrenia
- smooth pursuit
- visual
ASJC Scopus subject areas
- Cognitive Neuroscience
- Cellular and Molecular Neuroscience
Cite this
Diminished parietal cortex activity associated with poor motion direction discrimination performance in schizophrenia. / Wang, Jun; Brown, Ryan; Dobkins, Karen R.; McDowell, Jennifer E.; Clementz, Brett A.
In: Cerebral Cortex, Vol. 20, No. 7, 07.2010, p. 1749-1755.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Diminished parietal cortex activity associated with poor motion direction discrimination performance in schizophrenia
AU - Wang, Jun
AU - Brown, Ryan
AU - Dobkins, Karen R.
AU - McDowell, Jennifer E.
AU - Clementz, Brett A.
PY - 2010/7
Y1 - 2010/7
N2 - The results of multiple investigations indicate visual motion-processing abnormalities in schizophrenia. There is little information, however, about the time course and neural correlates of motion-processing abnormalities among these subjects. For the present study, 13 schizophrenia and 13 healthy subjects performed a simple motion direction discrimination task with peripherally presented moving grating stimuli (5 or 10 deg/s). Dense-array electroencephalography data were collected simultaneously. The goal was to discern whether neural deviations associated with motion-processing abnormalities among schizophrenia patients occur early or late in the visual-processing stream. Schizophrenia patients were worse at judging the direction of motion gratings, had enhanced early neural activity (about 90 ms after stimulus onset), and deficient target detection-related late neural activity over parietal cortex (about 400 ms after stimulus onset). In addition, there was a strong association (accounting for 36% of performance variance) between poor behavioral performance and lower target detection-related brain activity among schizophrenia patients. These findings suggest that abnormalities in later stages of motion-processing mechanisms, perhaps beyond extrastriate cortex, may account for behavioral deviations among schizophrenia subjects.
AB - The results of multiple investigations indicate visual motion-processing abnormalities in schizophrenia. There is little information, however, about the time course and neural correlates of motion-processing abnormalities among these subjects. For the present study, 13 schizophrenia and 13 healthy subjects performed a simple motion direction discrimination task with peripherally presented moving grating stimuli (5 or 10 deg/s). Dense-array electroencephalography data were collected simultaneously. The goal was to discern whether neural deviations associated with motion-processing abnormalities among schizophrenia patients occur early or late in the visual-processing stream. Schizophrenia patients were worse at judging the direction of motion gratings, had enhanced early neural activity (about 90 ms after stimulus onset), and deficient target detection-related late neural activity over parietal cortex (about 400 ms after stimulus onset). In addition, there was a strong association (accounting for 36% of performance variance) between poor behavioral performance and lower target detection-related brain activity among schizophrenia patients. These findings suggest that abnormalities in later stages of motion-processing mechanisms, perhaps beyond extrastriate cortex, may account for behavioral deviations among schizophrenia subjects.
KW - ERP
KW - motion
KW - motion processing
KW - P1
KW - parietal cortex
KW - schizophrenia
KW - smooth pursuit
KW - visual
UR - http://www.scopus.com/inward/record.url?scp=77955951718&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=77955951718&partnerID=8YFLogxK
U2 - 10.1093/cercor/bhp243
DO - 10.1093/cercor/bhp243
M3 - Article
C2 - 19915096
AN - SCOPUS:77955951718
VL - 20
SP - 1749
EP - 1755
JO - Cerebral Cortex
JF - Cerebral Cortex
SN - 1047-3211
IS - 7
ER -