Diminished parietal cortex activity associated with poor motion direction discrimination performance in schizophrenia

Jun Wang, Ryan Brown, Karen R. Dobkins, Jennifer E. McDowell, Brett A. Clementz

Research output: Contribution to journalArticle

22 Scopus citations

Abstract

The results of multiple investigations indicate visual motion-processing abnormalities in schizophrenia. There is little information, however, about the time course and neural correlates of motion-processing abnormalities among these subjects. For the present study, 13 schizophrenia and 13 healthy subjects performed a simple motion direction discrimination task with peripherally presented moving grating stimuli (5 or 10 deg/s). Dense-array electroencephalography data were collected simultaneously. The goal was to discern whether neural deviations associated with motion-processing abnormalities among schizophrenia patients occur early or late in the visual-processing stream. Schizophrenia patients were worse at judging the direction of motion gratings, had enhanced early neural activity (about 90 ms after stimulus onset), and deficient target detection-related late neural activity over parietal cortex (about 400 ms after stimulus onset). In addition, there was a strong association (accounting for 36% of performance variance) between poor behavioral performance and lower target detection-related brain activity among schizophrenia patients. These findings suggest that abnormalities in later stages of motion-processing mechanisms, perhaps beyond extrastriate cortex, may account for behavioral deviations among schizophrenia subjects.

Original languageEnglish (US)
Pages (from-to)1749-1755
Number of pages7
JournalCerebral Cortex
Volume20
Issue number7
DOIs
StatePublished - Jul 2010

Keywords

  • ERP
  • P1
  • motion
  • motion processing
  • parietal cortex
  • schizophrenia
  • smooth pursuit
  • visual

ASJC Scopus subject areas

  • Cognitive Neuroscience
  • Cellular and Molecular Neuroscience

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