Abstract
The results of multiple investigations indicate visual motion-processing abnormalities in schizophrenia. There is little information, however, about the time course and neural correlates of motion-processing abnormalities among these subjects. For the present study, 13 schizophrenia and 13 healthy subjects performed a simple motion direction discrimination task with peripherally presented moving grating stimuli (5 or 10 deg/s). Dense-array electroencephalography data were collected simultaneously. The goal was to discern whether neural deviations associated with motion-processing abnormalities among schizophrenia patients occur early or late in the visual-processing stream. Schizophrenia patients were worse at judging the direction of motion gratings, had enhanced early neural activity (about 90 ms after stimulus onset), and deficient target detection-related late neural activity over parietal cortex (about 400 ms after stimulus onset). In addition, there was a strong association (accounting for 36% of performance variance) between poor behavioral performance and lower target detection-related brain activity among schizophrenia patients. These findings suggest that abnormalities in later stages of motion-processing mechanisms, perhaps beyond extrastriate cortex, may account for behavioral deviations among schizophrenia subjects.
Original language | English (US) |
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Pages (from-to) | 1749-1755 |
Number of pages | 7 |
Journal | Cerebral Cortex |
Volume | 20 |
Issue number | 7 |
DOIs | |
State | Published - Jul 2010 |
Keywords
- ERP
- P1
- motion
- motion processing
- parietal cortex
- schizophrenia
- smooth pursuit
- visual
ASJC Scopus subject areas
- Cognitive Neuroscience
- Cellular and Molecular Neuroscience