Diminishing returns, increasing risks: Impact of antibiotic duration of therapy on respiratory bacterial isolates in hospitalized patients during the coronavirus disease 2019 (COVID-19) pandemic

Catherine Li, Ryan W. Chapin, Nicholas J. Mercuro, Christina F. Yen, Howard S. Gold, Matthew S.L. Lee, Christopher McCoy

Research output: Contribution to journalArticlepeer-review

Abstract

In 829 hospital encounters for patients with COVID-19, 73.2% included orders for antibiotics; however, only 1.8% had respiratory cultures during the first 3 hospital days isolating bacteria. Case-control analysis of 30 patients and 96 controls found that each antibiotic day increased the risk of isolating multidrug-resistant gram-negative bacteria (MDR-GNB) in respiratory cultures by 6.5%.

Original languageEnglish (US)
Article numbere13
JournalAntimicrobial Stewardship and Healthcare Epidemiology
Volume1
Issue number1
DOIs
StatePublished - Jul 23 2021
Externally publishedYes

ASJC Scopus subject areas

  • Infectious Diseases
  • Epidemiology
  • Microbiology (medical)

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