Dipolar cross-relaxation modulates signal amplitudes in the 1H NMR spectrum of hyperpolarized [13C]formate

Matthew E. Merritt, Crystal Harrison, William Mander, Craig R. Malloy, A. Dean Sherry

Research output: Contribution to journalArticle

23 Scopus citations

Abstract

The asymmetry in the doublet of a spin coupled to hyperpolarized 13C has been used previously to measure the initial polarization of 13C. We tested the hypothesis that a single observation of the 1H NMR spectrum of hyperpolarized 13C formate monitors 13C polarization. Depending on the microwave frequency during the polarization process, in-phase or out-of-phase doublets were observed in the 1H NMR spectrum. Even in this simple two-spin system, 13C polarization was not reflected in the relative area of the JCH doublet components due to strong heteronuclear cross-relaxation. The Solomon equations were used to model the proton signal as a function of time after polarization and to estimate 13C polarization from the 1H NMR spectra.

Original languageEnglish (US)
Pages (from-to)280-285
Number of pages6
JournalJournal of Magnetic Resonance
Volume189
Issue number2
DOIs
StatePublished - Dec 1 2007

Keywords

  • Dynamic nuclear polarization
  • Formate
  • Overhauser effect
  • SPINOE
  • Solomon equations

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Nuclear and High Energy Physics
  • Condensed Matter Physics

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