Dipolar cross-relaxation modulates signal amplitudes in the 1H NMR spectrum of hyperpolarized [13C]formate

Matthew E. Merritt, Crystal Harrison, William Mander, Craig R. Malloy, A. Dean Sherry

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

The asymmetry in the doublet of a spin coupled to hyperpolarized 13C has been used previously to measure the initial polarization of 13C. We tested the hypothesis that a single observation of the 1H NMR spectrum of hyperpolarized 13C formate monitors 13C polarization. Depending on the microwave frequency during the polarization process, in-phase or out-of-phase doublets were observed in the 1H NMR spectrum. Even in this simple two-spin system, 13C polarization was not reflected in the relative area of the JCH doublet components due to strong heteronuclear cross-relaxation. The Solomon equations were used to model the proton signal as a function of time after polarization and to estimate 13C polarization from the 1H NMR spectra.

Original languageEnglish (US)
Pages (from-to)280-285
Number of pages6
JournalJournal of Magnetic Resonance
Volume189
Issue number2
DOIs
StatePublished - Dec 2007

Fingerprint

formic acid
cross relaxation
formates
Nuclear magnetic resonance
Polarization
nuclear magnetic resonance
polarization
Microwaves
Protons
Microwave frequencies
microwave frequencies
Proton Magnetic Resonance Spectroscopy
monitors

Keywords

  • Dynamic nuclear polarization
  • Formate
  • Overhauser effect
  • Solomon equations
  • SPINOE

ASJC Scopus subject areas

  • Molecular Biology
  • Physical and Theoretical Chemistry
  • Spectroscopy
  • Radiology Nuclear Medicine and imaging
  • Condensed Matter Physics

Cite this

Dipolar cross-relaxation modulates signal amplitudes in the 1H NMR spectrum of hyperpolarized [13C]formate. / Merritt, Matthew E.; Harrison, Crystal; Mander, William; Malloy, Craig R.; Dean Sherry, A.

In: Journal of Magnetic Resonance, Vol. 189, No. 2, 12.2007, p. 280-285.

Research output: Contribution to journalArticle

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